Accession
MI0000238
Symbol
HGNC:
MIR196A1
Description
Homo sapiens
hsa-mir-196a-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR196A1 is a microRNA gene located within the homeobox (HOX) gene clusters on human chromosome 17q21.32 and plays a role in gene expression regulation [PMC5533727]. It belongs to the miR-196 family, which includes MIR196A2 and MIR196B, and it shares identical mature nucleotide sequences with MIR196A2 [PMC4413621]. This family of miRNAs is involved in various biological processes and diseases, with MIR196A1 expression being correlated with obesity-related traits such as body fat percentage and waist circumference [PMC5551414]. Additionally, MIR196A1 is linked to the regulation of HOX genes, associating with HOXB7, HOXB8, and HOTAIR [PMC5551414]. Aberrant expression of MIR196A1 has been noted in pancreatic cancer cells, influencing apoptosis, invasion, and proliferation [PMC4454596]. Furthermore, MIR196A1 is significant in cancer biology and serves as a potential biomarker for endometrial carcinoma (ECa) [PMC10134363]. Contrary to previous claims, there have been reports of aberrant methylation of MIR196A1 in human cancers, and methylation levels of this miRNA are inversely associated with the duration of smoking cessation [PMC5960087].
Literature search
215 open access papers mention hsa-mir-196a-1
(1246 sentences)
(1246 sentences)
Sequence
150959
reads,
1109
reads per million, 95 experiments
gugaauUAGGUAGUUUCAUGUUGUUGGGccuggguuucugaacaCAACAACAUUAAACCACCCGAuucac
(((((((.(((.((((.((((((((((..(.........)..).))))))))).)))).))).)))))))
(((((((.(((.((((.((((((((((..(.........)..).))))))))).)))).))).)))))))
Structure
A A C - Gc ugg
gugaauU GGU GUUU AUGUUGUUG G c g
||||||| ||| |||| ||||||||| | | u
cacuuAG CCA CAAA UACAACAAC c g u
C C U a aa ucu
Annotation confidence
High
Do you think this miRNA is real?
Comments
Lagos-Quintana et al. [1] cloned this miRNA from human osteoblast sarcoma cells. Lim et al [2] independently predicted this miRNA by computational methods using conservation with mouse and Fugu rubripes sequences [2]. Expression of the excised miR was validated in zebrafish. The sequence maps to human chromosome 17. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr17: 48632490-48632559 [-]
Disease association
hsa-mir-196a-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-196a-1 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-196a-1 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-196a-5p
| Accession | MIMAT0000226 |
| Description | Homo sapiens hsa-miR-196a-5p mature miRNA |
| Sequence | 7 - UAGGUAGUUUCAUGUUGUUGGG - 28 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-196a-1-3p
| Accession | MIMAT0037307 |
| Description | Homo sapiens hsa-miR-196a-1-3p mature miRNA |
| Sequence | 45 - CAACAACAUUAAACCACCCGA - 65 |
| Evidence | not_experimental |
References
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