miRBase entry: mmu-mir-155

Stem-loop mmu-mir-155


Accession
MI0000177
Symbol
MGI: Mir155
Description
Mus musculus mmu-mir-155 precursor miRNA mir-155
Gene
family?
RF00731; mir-155

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Mmu-mir-155 is a type of microRNA that has been studied in various contexts [PMC8387184]. One study found that GLGZD treatment significantly suppressed the upregulation of mmu-mir-155 and increased the expression of SOCS1, SMAD1, SHIP1, and TAB2 mRNA induced by OGD [PMC8387184]. Another study observed that mmu-mir-155 was significantly up-regulated in the mid-phase of infection [PMC3692539]. In terms of miRNA expression analysis, mmu-mir-155 was reverse transcribed from RNA using a Taqman miRNA Reverse Transcription kit [PMC8368181]. These findings suggest that mmu-mir-155 may play a role in various biological processes and could be a potential target for therapeutic interventions [PMC8387184][PMC3692539][PMC8368181[PMC3692539][PMC8368181]. However, further research is needed to fully understand the functions and mechanisms of mmu-mir-155 in different contexts [PMC8387184][PMC3692539][PMC8368181[PMC3692539][PMC8368181].

Literature search
508 open access papers mention mmu-mir-155
(8083 sentences)

Sequence

115386 reads, 616 reads per million, 101 experiments
cugUUAAUGCUAAUUGUGAUAGGGGUuuuggccucugacugaCUCCUACCUGUUAGCAUUAACag
((((((((((((((.(.(.((((((((..(........).)))))))))).))))))))))))))

Structure
              U U A        uu gcc 
cugUUAAUGCUAAU G G UAGGGGUu  g   u
|||||||||||||| | | ||||||||  |    
gaCAAUUACGAUUG C C AUCCUCag  c   c
              U - -        -u agu 


Annotation confidence High
Do you think this miRNA is real?
Comments
Mouse mir-155 resides in the non-coding BIC transcript (EMBL:AY096003), located on chromosome 16 [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr16: 84714140-84714204 [+]

Database links

Mature mmu-miR-155-5p

Accession MIMAT0000165
Description Mus musculus mmu-miR-155-5p mature miRNA
Sequence 4 - UUAAUGCUAAUUGUGAUAGGGGU - 26
Evidence experimental
cloned [1,3], Illumina [5]
Database links
Predicted targets

Mature mmu-miR-155-3p

Accession MIMAT0016993
Description Mus musculus mmu-miR-155-3p mature miRNA
Sequence 43 - CUCCUACCUGUUAGCAUUAAC - 63
Evidence experimental
454 [4], Illumina [5]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  4. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  5. PubMed ID: 20668074
    Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
    "Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H"
    "J Virol (2010) 84:10266-10275