Stem-loop hsa-mir-107

Accession

MI0000114

Symbol

HGNC: MIR107

Description

Homo sapiens hsa-mir-107 precursor miRNA mir-103

Gene
family

RF00129; mir-103

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

The microRNA hsa-mir-107 has been identified as significantly upregulated in the FGD5-AS1 KD CCC-HEH-2 cell line, which could indicate its involvement in specific cellular functions within this system [PMC8144506]. This cell line originates from cholangiocarcinoma, a cancer affecting the bile ducts, and the observed upregulation of hsa-mir-107 suggests it may influence the behavior of these cancer cells [PMC8144506]. In addition, hsa-mir-107 is also recognized for its potential tumor-suppressive effects in non-small cell lung cancer (NSCLC) cells, highlighting its relevance in cancer research [PMC6981095]. The connections of hsa-mir-107 with various cancer types underscore its significance in the field of cancer biology and emphasize the need for further studies to elucidate its role and therapeutic possibilities [PMC8144506; PMC6981095]..

Literature search

185 open access papers mention hsa-mir-107
(941 sentences)

Sequence

4415819 reads, 14654 reads per million, 155 experiments

cucucugcuuucagcuucuuuacaguguugccuuguggcauggaguucaAGCAGCAUUGUACAGGGCUAUCAaagcacaga
.(((.((((((.((((.((.(((((((((((.(((.(((.....))))))))))))))))).))))))...)))))).)))

Structure

c   c      --c    u  u           c   u   a 
 ucu ugcuuu   agcu cu uacaguguugc uug ggc u
 ||| ||||||   |||| || ||||||||||| ||| ||| g
 aga acgaaA   UCGG GA AUGUUACGACG Aac uug g
-   c      CUA    -  C           -   -   a 

Annotation confidence High

Comments

This miRNA was identified by homology to miR-103 [1], and later verified by cloning in human [2].

Genome context

chr10: 89592747-89592827 [-]

Disease association

hsa-mir-107 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-107

• Accession: MIMAT0000104
• Description: Homo sapiens hsa-miR-107 mature miRNA
• Sequence: 50 - AGCAGCAUUGUACAGGGCUAUCA - 72
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 11914277
   miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
   "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
   "Genes Dev (2002) 16:720-728