Accession
MI0000105
Symbol
HGNC:
MIR29B1
Description
Homo sapiens
hsa-mir-29b-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR29B1 is a microRNA gene that encodes for the miR-29b-3p sequence, a member of the miR-29 family, which is implicated in various cellular processes and diseases [PMC9601486]. In the context of Alzheimer's disease (AD), MIR29B1 has been found to be downregulated in the cortex of AD patients, suggesting a potential role in the disease's pathogenesis [PMC7564652]. This downregulation may influence AD by targeting genes directly involved in its pathogenesis, such as BACE1, which is involved in amyloid precursor protein processing [PMC7564652]. Additionally, MIR29B1's downregulation could indirectly affect neuron survival and thus contribute to AD progression [PMC7564652]. In other studies, MIR29B1 has been associated with various biological processes; for instance, it has been implicated in increasing milk yield in dairy cattle when co-expressed with MIR148A [PMC6898964], and its upregulation was observed upon knockdown of LASP-1 correlating with reduced MMP9 transcript levels in MDA-MB-231S cells [PMC4651668]. Furthermore, mutations in MIR29B1 have been linked to altered physiological responses such as reduced urine volume and increased renal fibrosis under certain dietary conditions in rats [PMC6156712], highlighting its significance beyond neurodegenerative diseases.
Literature search
661 open access papers mention hsa-mir-29b-1
(4447 sentences)
(4447 sentences)
Sequence
369151
reads,
2447
reads per million, 159 experiments
cuucaggaaGCUGGUUUCAUAUGGUGGUUUAGAuuuaaauagugauugucUAGCACCAUUUGAAAUCAGUGUUcuuggggg
(((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))).
(((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))).
Structure
- - U GU uuaaa cuucaggaa GCUGGUUUCA AUGGUG UUAGAu u ||||||||| |||||||||| |||||| |||||| a gggguucUU UGACUAAAGU UACCAC GAUcug g g G U -- uuagu
Annotation confidence
High
Do you think this miRNA is real?
Comments
Mourelatos et al. identified two copies of this sequence mapping to chromosome 7, and assigned the names mir-102-7.1 and mir-102-7.2 [1]. Subsequent genome assemblies suggest the presence of only one miR-102 locus on chromosome 7. Human miR-102 is a homologue of mouse miR-29b (MIR:MI0000143) and so has been renamed here for consistency.
Genome context
chr7: 130877459-130877539 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-29b-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-29b-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-29b-1-5p
| Accession | MIMAT0004514 |
| Description | Homo sapiens hsa-miR-29b-1-5p mature miRNA |
| Sequence | 10 - GCUGGUUUCAUAUGGUGGUUUAGA - 33 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-29b-3p
| Accession | MIMAT0000100 |
| Description | Homo sapiens hsa-miR-29b-3p mature miRNA |
| Sequence | 51 - UAGCACCAUUUGAAAUCAGUGUU - 73 |
| Evidence |
experimental
cloned [1-4], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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