Accession
MI0000100
Symbol
HGNC:
MIR98
Description
Homo sapiens
hsa-mir-98 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR98 is a microRNA implicated in the regulation of breast cancer metastasis, as evidenced by in vivo experiments where MDA-MB-231 breast cancer cells, infected with a lentivirus carrying MIR98, were inoculated into the mammary fat pads of nude mice and stimulated with CCL18 [PMC4653020]. This microRNA was among seven selected for validation of array-based expression data using Taqman quantitative RT-PCR, highlighting its significance in the study [PMC3288043]. Furthermore, MIR98 is involved in a regulatory pathway where its expression is increased upon the silencing of N-Ras, leading to the inactivation of the ERK/PI3K/NFκB/Lin28b pathway and loss of its inhibitor Lin28b; this upregulation of MIR98 contributes to further inhibition of N-Ras expression [PMC4653020].
Literature search
137 open access papers mention hsa-mir-98
(565 sentences)
(565 sentences)
Sequence
58305
reads,
616
reads per million, 132 experiments
aggauucugcucaugccagggUGAGGUAGUAAGUUGUAUUGUUgugggguagggauauuaggccccaauuagaagauaaCUAUACAACUUACUACUUUCCCugguguguggcauauuca
.((((..((((((((((((((.(((((((((((((((((.((((((((((...........)))))).........)))).))))))))))))))))))))))))))).)))).)))).
.((((..((((((((((((((.(((((((((((((((((.((((((((((...........)))))).........)))).))))))))))))))))))))))))))).)))).)))).
Structure
a uc - U U --------- aggg ggau ugcu caugccaggg GAGGUAGUAAGUUGUAU GUUg uggggu a |||| |||| |||||||||| ||||||||||||||||| |||| |||||| u cuua acgg gugugguCCC UUUCAUCAUUCAACAUA Caau accccg a a -u u - U agaagauua gauu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is localised to chromosome X and was named mir-98-X in reference [1]. The predicted stem-loop precursor sequence is clearly related to let-7.
Genome context
chrX: 53556223-53556341 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-98
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-98 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-98 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-98 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-98-5p
| Accession | MIMAT0000096 |
| Description | Homo sapiens hsa-miR-98-5p mature miRNA |
| Sequence | 22 - UGAGGUAGUAAGUUGUAUUGUU - 43 |
| Evidence |
experimental
cloned [1-3], SOLiD [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-98-3p
| Accession | MIMAT0022842 |
| Description | Homo sapiens hsa-miR-98-3p mature miRNA |
| Sequence | 80 - CUAUACAACUUACUACUUUCCC - 101 |
| Evidence |
experimental
SOLiD [4] |
| Database links |
|
| Predicted targets |
|
References
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