Accession
MI0000100
Symbol
HGNC:
MIR98
Description
Homo sapiens
hsa-mir-98 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR98 is a microRNA that has been implicated in breast cancer metastasis [PMC4653020]. In a study conducted on nude mice, MDA-MB-231 breast cancer cells infected with lentivirus carrying either MIR98 or a control (NC) were stimulated with CCL18, and their metastatic potential was evaluated [PMC4653020]. Among several microRNAs, including miR-18a, miR-21, miR-26a, miR-26b, miR-30b, MIR98 and miR-210, MIR98 was selected for further validation using Taqman quantitative RT-PCR [PMC3288043]. The study also found that when N-Ras is silenced in breast cancer cells, the ERK/PI3K/NFκB/Lin28b pathway is inactivated. This inactivation leads to the loss of Lin28b as an inhibitor of MIR98 and subsequently results in higher levels of MIR98. The increased levels of MIR98 further inhibit the expression of N-Ras [PMC4653020]. These findings suggest that reduction in MIR98 expression may contribute to enhanced breast cancer metastasis when stimulated by CCL18 [PMC4653020].
Literature search
137 open access papers mention hsa-mir-98
(565 sentences)
(565 sentences)
Sequence
58305
reads,
616
reads per million, 132 experiments
aggauucugcucaugccagggUGAGGUAGUAAGUUGUAUUGUUgugggguagggauauuaggccccaauuagaagauaaCUAUACAACUUACUACUUUCCCugguguguggcauauuca
.((((..((((((((((((((.(((((((((((((((((.((((((((((...........)))))).........)))).))))))))))))))))))))))))))).)))).)))).
.((((..((((((((((((((.(((((((((((((((((.((((((((((...........)))))).........)))).))))))))))))))))))))))))))).)))).)))).
Structure
a uc - U U --------- aggg ggau ugcu caugccaggg GAGGUAGUAAGUUGUAU GUUg uggggu a |||| |||| |||||||||| ||||||||||||||||| |||| |||||| u cuua acgg gugugguCCC UUUCAUCAUUCAACAUA Caau accccg a a -u u - U agaagauua gauu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is localised to chromosome X and was named mir-98-X in reference [1]. The predicted stem-loop precursor sequence is clearly related to let-7.
Genome context
chrX: 53556223-53556341 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-98
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-98 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-98 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-98 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-98-5p
| Accession | MIMAT0000096 |
| Description | Homo sapiens hsa-miR-98-5p mature miRNA |
| Sequence | 22 - UGAGGUAGUAAGUUGUAUUGUU - 43 |
| Evidence |
experimental
cloned [1-3], SOLiD [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-98-3p
| Accession | MIMAT0022842 |
| Description | Homo sapiens hsa-miR-98-3p mature miRNA |
| Sequence | 80 - CUAUACAACUUACUACUUUCCC - 101 |
| Evidence |
experimental
SOLiD [4] |
| Database links |
|
| Predicted targets |
|
References
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