Stem-loop hsa-mir-33a

Accession

MI0000091

Symbol

HGNC: MIR33A

Description

Homo sapiens hsa-mir-33a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-33a, a microRNA, has been implicated in various cellular processes and diseases, including cancer. In hepatocellular carcinoma (HCC), a reduction in hsa-mir-33a levels is linked to tumorigenesis and is indicative of a poor prognosis [PMC8615810]. Additionally, hsa-mir-33a plays a role in modulating the resistance of HCC cells to the chemotherapy drug cisplatin [PMC9200351]. In macrophages, hsa-mir-33a mimic treatment results in decreased expression of proteins involved in autophagy compared to control treatments [PMC4873392]. Dysregulation of hsa-mir-33a has also been observed in patients with HIV, where it is consistently downregulated [PMC8615810]. Furthermore, it serves as a hub gene within ceRNA networks associated with esophageal cancer (EC) progression [PMC9200351], and hypomethylation at the SREBF2 gene body including the hsa-mir-33a locus may lead to SREBF2 downregulation [PMC9789638]. Hsa-mir-33a also influences gestational diabetes mellitus (GDM) through its regulatory effects on genes like MAP4K3 which are hypomethylated and upregulated in GDM [PMC8257864]. Lastly, it is part of an 8-miRNA signature identified as having significant prognostic potential for colorectal cancer (CRC) patients [PMC8299930]. The statement about hsa-mir-33a regulating the expression of neuropilin-2 and inhibiting glioblastoma cell migration has been removed as it incorrectly referred to hsa-mir-331 instead of hsa-mir-33a [PMC8843861].

Literature search

157 open access papers mention hsa-mir-33a
(1512 sentences)

Sequence

98359 reads, 793 reads per million, 116 experiments

cugugGUGCAUUGUAGUUGCAUUGCAuguucuggugguacccaugCAAUGUUUCCACAGUGCAUCACag
((((((((((((((.(..((((((((((....(((...)))))))))))))..).))))))))))))))

Structure

              A UU          uucu   g 
cugugGUGCAUUGU G  GCAUUGCAug    ggu  
|||||||||||||| |  ||||||||||    ||| g
gaCACUACGUGACA C  UGUAACguac    cca  
              C UU          ----   u 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr22: 41900944-41901012 [+]

Disease association

hsa-mir-33a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-33a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-33a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-33a-5p

• Accession: MIMAT0000091
• Description: Homo sapiens hsa-miR-33a-5p mature miRNA
• Sequence: 6 - GUGCAUUGUAGUUGCAUUGCA - 26
• Evidence: experimental ; cloned [1-2], Northern [1]

Mature hsa-miR-33a-3p

• Accession: MIMAT0004506
• Description: Homo sapiens hsa-miR-33a-3p mature miRNA
• Sequence: 46 - CAAUGUUUCCACAGUGCAUCAC - 67
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414