Accession
MI0000086
Symbol
HGNC:
MIR28
Description
Homo sapiens
hsa-mir-28 precursor miRNA mir-28
Gene
family?
family?
RF00655;
mir-28
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR28 is a type of microRNA that has been shown to repress the expression of ΔVSP-175-myc, IGF1, and MDSC percentage in various experiments [PMC3937270] [PMC7782091]. In one study, the combination of MIR28 and miR83 was found to decrease ΔVSP-175-myc expression to 48%, while the combination of miR86, MIR28, and miR83 decreased expression to 33%, and the combination of miR88, miR86, MIR28, and miR83 decreased expression to 19% [PMC3937270]. In another study using a co-culture system, knockdown of miR21 and miR130b along with overexpression of MIR28 resulted in a significant decrease in IGF1 expression (P = 0.005) and MDSC percentage (P = 0.005) [PMC7782091]. These findings suggest that MIR28 plays a role in regulating the expression of various genes involved in different biological processes.
Literature search
90 open access papers mention hsa-mir-28
(309 sentences)
(309 sentences)
Sequence
150537
reads,
1128
reads per million, 158 experiments
gguccuugcccucAAGGAGCUCACAGUCUAUUGAGuuaccuuucugacuuuccCACUAGAUUGUGAGCUCCUGGAgggcaggcacu
(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).)))
(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).)))
Structure
c A U ---- cc ggu cuugcccuc AGGAGCUCACAGUCUA UG AGuua u ||| ||||||||| |||||||||||||||| || ||||| uca ggacgggAG UCCUCGAGUGUUAGAU AC ucagu u c G C ccuu cu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr3: 188688781-188688866 [+]
Disease association
hsa-mir-28 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-28-5p
| Accession | MIMAT0000085 |
| Description | Homo sapiens hsa-miR-28-5p mature miRNA |
| Sequence | 14 - AAGGAGCUCACAGUCUAUUGAG - 35 |
| Evidence |
experimental
cloned [1-3], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-28-3p
| Accession | MIMAT0004502 |
| Description | Homo sapiens hsa-miR-28-3p mature miRNA |
| Sequence | 54 - CACUAGAUUGUGAGCUCCUGGA - 75 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
References
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