Accession
MI0000084
Symbol
HGNC:
MIR26B
Description
Homo sapiens
hsa-mir-26b precursor miRNA mir-26
Gene
family?
family?
RF00244;
mir-26
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR26B is a microRNA implicated in the regulation of gene expression, specifically involved in the repression of EZH2, an enzyme that contributes to gene silencing through histone methylation [PMC6925750]. The genetic locus of MIR26B has been experimentally manipulated by incorporating loxP sites, a technique that allows for the conditional deletion of the 160 base pair segment of genomic DNA containing MIR26B [PMC8243710]. This modification is significant for research as it enables scientists to study the functional consequences of MIR26B deletion on EZH2 expression and potentially on broader genomic regulation mechanisms.
Literature search
259 open access papers mention hsa-mir-26b
(1137 sentences)
(1137 sentences)
Sequence
906667
reads,
3586
reads per million, 152 experiments
ccgggacccagUUCAAGUAAUUCAGGAUAGGUugugugcuguccagCCUGUUCUCCAUUACUUGGCUcggggaccgg
((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..))))
((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..))))
Structure
ga - U UC u ug
ccgg ccc agU CAAGUAAU AGGAUAGGUug g c
|||| ||| ||| |||||||| ||||||||||| |
ggcc ggg UCG GUUCAUUA UCUUGUCCgac c u
ag c - CC - ug
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr2: 218402646-218402722 [+]
Disease association
hsa-mir-26b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-26b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-26b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-26b-5p
| Accession | MIMAT0000083 |
| Description | Homo sapiens hsa-miR-26b-5p mature miRNA |
| Sequence | 12 - UUCAAGUAAUUCAGGAUAGGU - 32 |
| Evidence |
experimental
cloned [1,3-5], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-26b-3p
| Accession | MIMAT0004500 |
| Description | Homo sapiens hsa-miR-26b-3p mature miRNA |
| Sequence | 47 - CCUGUUCUCCAUUACUUGGCU - 67 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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