miRBase entry: hsa-mir-22

Stem-loop hsa-mir-22

Homo sapiens hsa-mir-22 precursor miRNA
Gene family
MIPF0000053; mir-22

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR22 is a microRNA that has been studied in relation to various biological processes. In a study conducted on U251 and EA.hy926 cells, the knockdown of RPL29 using siRNA, followed by poly(I:C) treatment, resulted in the quantification of MIR22 using qRT-PCR [PMC7530758]. The study found that the differential expression of MIR22 can regulate inflammation induced by the transmissible gastroenteritis virus in intestinal porcine epithelial cells [PMC7530758]. Another study observed that low expression of MIR22 was associated with poor prognosis in patients with hepatocellular carcinoma [PMC9284388]. However, further research is needed to fully understand the regulatory pathways through which RPL29 influences MIR22 expression [PMC7530758]. These findings highlight the potential role of MIR22 in inflammation and disease progression and emphasize the need for further investigation to elucidate its mechanisms of action.

Literature search
294 open access papers mention hsa-mir-22
(1734 sentences)


351813 reads, 2726 reads per million, 144 experiments

   u   cc               -     A      u  ccu 
ggc gag  gcaguAGUUCUUCAG UGGCA GCUUUA gu   g
||| |||  ||||||||||||||| ||||| |||||| ||   a
ccg cuc  cguUGUCAAGAAGUU ACCGU CGAAau cg   c
   u   -c               G     -      -  acc 

Annotation confidence High
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Genome context
chr17: 1713903-1713987 [-]

Disease association
hsa-mir-22 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-22 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-22 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-22-5p

Accession MIMAT0004495
Description Homo sapiens hsa-miR-22-5p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets

Mature hsa-miR-22-3p

Accession MIMAT0000077
Description Homo sapiens hsa-miR-22-3p mature miRNA
Evidence experimental
cloned [1,3-5], Northern [1], Illumina [6]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  6. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854