Accession
MI0000073
Symbol
HGNC:
MIR19A
Description
Homo sapiens
hsa-mir-19a precursor miRNA mir-19
Gene
family?
family?
RF00245;
mir-19
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR19A is a microRNA involved in gene regulation, and its overexpression has been linked to the activation of the transcription factor MYC, which is regulated by two signaling pathways [PMC8002730]. This activation of MYC subsequently leads to the increased expression of several downstream regulators, including NFE2L1, FOXC1, and notably MIR19A itself [PMC8002730]. In a study examining placental samples, MIR19A was among a group of microRNAs found to be upregulated in cases where mothers gave birth to macrosomic babies [PMC5572592]. This suggests that MIR19A may play a role in fetal growth and could be associated with macrosomia when overexpressed [PMC5572592].
Literature search
313 open access papers mention hsa-mir-19a
(1597 sentences)
(1597 sentences)
Sequence
545193
reads,
9302
reads per million, 118 experiments
gcaguccucuguuAGUUUUGCAUAGUUGCACUACAagaagaauguaguUGUGCAAAUCUAUGCAAAACUGAugguggccugc
((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).))))
((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).))))
Structure
u u -- --- ag
gcag cc cuguuAGUUUUGCAUAG UUGCAC UACA a
|||| || ||||||||||||||||| |||||| |||| a
cguc gg gguAGUCAAAACGUAUC AACGUG augu g
c u UA Uug aa
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference [2].
Genome context
chr13: 91350891-91350972 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-19a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-19a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-19a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-19a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-19a-5p
| Accession | MIMAT0004490 |
| Description | Homo sapiens hsa-miR-19a-5p mature miRNA |
| Sequence | 14 - AGUUUUGCAUAGUUGCACUACA - 35 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-19a-3p
| Accession | MIMAT0000073 |
| Description | Homo sapiens hsa-miR-19a-3p mature miRNA |
| Sequence | 49 - UGUGCAAAUCUAUGCAAAACUGA - 71 |
| Evidence |
experimental
cloned [1-5], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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