Stem-loop hsa-let-7e

Accession

MI0000066

Symbol

HGNC: MIRLET7E

Description

Homo sapiens hsa-let-7e precursor miRNA

Literature search

1095 open access papers mention hsa-let-7e
(6132 sentences)

Sequence

1076185 reads, 4220 reads per million, 133 experiments

cccgggcUGAGGUAGGAGGUUGUAUAGUUgaggaggacacccaaggagaucaCUAUACGGCCUCCUAGCUUUCCccagg
((.(((..(((.((((((((((((((((.((((.(....))).......)))))))))))))))))).)))..))).))

Structure

  c   cU   G                U  -------  a g 
cc ggg  GAG UAGGAGGUUGUAUAGU ga       gg g a
|| |||  ||| |||||||||||||||| ||       || |  
gg ccC  UUC AUCCUCCGGCAUAUCa cu       cc c c
  a   CU   G                -  agaggaa  - a 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr19: 51692786-51692864 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-let-7e

Disease association

hsa-let-7e is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-let-7e-5p

• Accession: MIMAT0000066
• Description: Homo sapiens hsa-let-7e-5p mature miRNA
• Sequence: 8 - UGAGGUAGGAGGUUGUAUAGUU - 29
• Evidence: experimental ; cloned [1-4], Northern [1], Illumina [5]

Mature hsa-let-7e-3p

• Accession: MIMAT0004485
• Description: Homo sapiens hsa-let-7e-3p mature miRNA
• Sequence: 53 - CUAUACGGCCUCCUAGCUUUCC - 74
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


3. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


4. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


5. PubMed ID: 20158877
   Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
   Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
   BMC Genomics (2010) 11:S6