Stem-loop cel-mir-1

Accession

MI0000003

Description

Caenorhabditis elegans cel-mir-1 precursor miRNA

Literature search

28 open access papers mention cel-mir-1
(107 sentences)

Sequence

12124625 reads, 57412 reads per million, 16 experiments

aaagugaccguaccgagcugCAUACUUCCUUACAUGCCCAUAcuauaucauaaauggauaUGGAAUGUAAAGAAGUAUGUAgaacggggugguagu
......((((..(((..(((((((((((.((((((..(((((((((.......)))).))))).)))))).)))))))))))..)))..))))...

Structure

aaagug    ua   ag           C      GC     -    au 
      accg  ccg  cugCAUACUUC UUACAU  CCAUA cuau  c
      ||||  |||  ||||||||||| ||||||  ||||| ||||  a
      uggu  ggc  gAUGUAUGAAG AAUGUA  GGUau ggua  u
---uga    gg   aa           A      -A     a    aa 

Annotation confidence High

Comments

miR-1 was independently identified in C. elegans [1,2] and Drosophila melanogaster (MIR:MI0000116) [3]. The sequence is also conserved in C. briggsae (MIR:MI0000493).

Genome context

chrI: 6172662-6172757 [-]

Mature cel-miR-1-3p

• Accession: MIMAT0000003
• Description: Caenorhabditis elegans cel-miR-1-3p mature miRNA
• Sequence: 61 - UGGAAUGUAAAGAAGUAUGUA - 81
• Evidence: experimental ; cloned [1-2,4-5], Northern [1], Illumina [10,8], PCR [6], 454 [7], CLIPseq [9]

Mature cel-miR-1-5p

• Accession: MIMAT0020301
• Description: Caenorhabditis elegans cel-miR-1-5p mature miRNA
• Sequence: 21 - CAUACUUCCUUACAUGCCCAUA - 42
• Evidence: experimental ; Illumina [10]

References

1. PubMed ID: 11679671
   An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
   "Lau NC, Lim LP, Weinstein EG, Bartel DP"
   "Science (2001) 294:858-862


2. PubMed ID: 12672692
   The microRNAs of Caenorhabditis elegans
   "Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP"
   "Genes Dev (2003) 17:991-1008


3. PubMed ID: 12747828
   MicroRNAs and other tiny endogenous RNAs in C. elegans
   "Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D"
   "Curr Biol (2003) 13:807-818


4. PubMed ID: 12769849
   Computational and experimental identification of C. elegans microRNAs
   "Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J"
   "Mol Cell (2003) 11:1253-1263


5. PubMed ID: 17174894
   Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
   "Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H, Bartel DP"
   "Cell (2006) 127:1193-1207


6. PubMed ID: 19460142
   Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
   Kato M, de Lencastre A, Pincus Z, Slack FJ
   Genome Biol (2009) 10:R54


7. PubMed ID: 20062054
   Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
   "Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW"
   "Nat Struct Mol Biol (2010) 17:173-179


8. PubMed ID: 11679672
   An extensive class of small RNAs in Caenorhabditis elegans
   "Lee RC, Ambros V"
   "Science (2001) 294:862-864


9. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


10. PubMed ID: 21307183
    Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer
    "Warf MB, Johnson WE, Bass BL"
    "RNA (2011) 17:563-577