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3 publications mentioning rno-mir-741Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-741. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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| 1 |
Other miRNAs from this paper: hsa-mir-26a-1, hsa-mir-26b, mmu-mir-141, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, mmu-mir-205, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-205, hsa-mir-200b, mmu-mir-290a, mmu-mir-291a, mmu-mir-292a, mmu-mir-293, mmu-mir-294, mmu-mir-295, mmu-mir-302a, hsa-mir-141, mmu-mir-200a, mmu-mir-26a-1, mmu-mir-26b, hsa-mir-200c, mmu-mir-200c, mmu-mir-26a-2, mmu-mir-199a-2, mmu-mir-199b, hsa-mir-200a, hsa-mir-302a, hsa-mir-26a-2, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, hsa-mir-372, rno-mir-26a, rno-mir-26b, rno-mir-141, rno-mir-199a, rno-mir-200c, rno-mir-200a, rno-mir-200b, rno-mir-205, rno-mir-290, rno-mir-291a, rno-mir-292, hsa-mir-429, mmu-mir-429, rno-mir-429, mmu-mir-463, mmu-mir-465a, mmu-mir-471, mmu-mir-367, mmu-mir-291b, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, mmu-mir-741, mmu-mir-743a, mmu-mir-743b, mmu-mir-871, mmu-mir-880, mmu-mir-881, mmu-mir-883a, mmu-mir-883b, mmu-mir-465b-1, mmu-mir-465b-2, mmu-mir-465c-1, mmu-mir-465c-2, mmu-mir-878, rno-mir-743b, rno-mir-871, rno-mir-878, rno-mir-880, rno-mir-881, rno-mir-883, rno-mir-463, rno-mir-471, rno-mir-743a, hsa-mir-302e, hsa-mir-302f, rno-mir-293, rno-mir-294, rno-mir-295-1, rno-mir-465, rno-mir-3551, rno-mir-291b, rno-mir-3580, rno-mir-295-2, rno-mir-6325, mmu-mir-292b, mmu-mir-465d, mmu-mir-290b
Several miRNAs, such as members of the miR-183-96-182 cluster, miR-741, miR-881, miR-878, miR-743a, miR-743b, miR-465, miR-871, miR-880, are known to be expressed in mouse ESCs and were also expressed in rat PSCs; however, their function in pluripotency induction and regulation has not been directly shown 48– 50.
[score:7]
We also analysed the expression of the rno-miR-novel-8 miRNA, rno-miR-sno-57 miRNA, miR-741-3p, and miR-743a-3p, which are upregulated in PSCs during differentiation.
[score:6]
Using qPCR, we have shown that members of the miR-741-3p and miR-743a-3p clusters were expressed at high levels in rat ESCs and iPSCs and were downregulated during differentiation.
[score:6]
rno-miR-novel-8, rno-homolog-miR-26, and rno-homolog-miR-199 miRNAs were selected from Tier 1, and rno-miR-sno-57 miRNA was selected from Tier 2. In addition, we analysed the expression of miR-741-3p and miR-743a-3p and found that, in accordance with sequencing data, they were highly expressed in rat PSCs.
[score:5]
We found that miR-741-3p, miR-743a-3p, and rno-miR-novel-8 miRNA were expressed in the testis at levels comparable to that in PSCs.
[score:3]
A cluster of miRNAs, comprised of miR-463, miR-465, miR-471, miR-741, miR-743a, miR-743b, miR-871, miR-878, miR-880, miR-881, and miR-883, was located on the X chromosome and was expressed at a high level in rat PSCs according to the sequencing data.
[score:3]
miR-741-3p was also expressed in the lungs, ovaries and spleen but at lower levels (Fig. 4c).
[score:3]
qRT-PCR analysis demonstrated that the rno-miR-novel-8 and rno-miR-sno-57 miRNAs as well as the known miRNAs miR-741-3p and miR-743a-3p were expressed in rat PSCs and absent in rat EFs (Fig. 4a).
[score:3]
We found that rat miR-295-3p, miR-741-3p and miR-743a-3p expression was significantly decreased during ESC and iPSC differentiation (Fig. 4b).
[score:3]
[1 to 20 of 9 sentences]
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| 2 |
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, mmu-mir-202, hsa-mir-208a, mmu-mir-122, hsa-mir-34a, mmu-mir-293, hsa-mir-122, mmu-mir-208a, mmu-let-7a-1, mmu-let-7a-2, mmu-mir-34a, mmu-mir-7b, hsa-mir-376c, hsa-mir-376a-1, hsa-mir-377, mmu-mir-376a, mmu-mir-377, rno-let-7a-1, rno-let-7a-2, rno-mir-7b, rno-mir-34a, rno-mir-122, rno-mir-208a, mmu-mir-376b, mmu-mir-463, hsa-mir-376b, hsa-mir-202, rno-mir-377, hsa-mir-376a-2, mmu-mir-376c, rno-mir-376c, rno-mir-376b, rno-mir-376a, mmu-mir-741, mmu-mir-742, mmu-mir-208b, hsa-mir-208b, rno-mir-463, rno-mir-742, rno-mir-202, rno-mir-293, rno-mir-208b
Expression of rno-mir-741-3p and mir-742-3p, which reside in the mir-463 genomic cluster and is thus likely to be expressed as a single transcript [54], is strain-specific.
[score:5]
Notably the strongest diverged arm of rno-mir-741is the most abundant arm in our cloning data (Additional file 12, Figure S4B) and is the only miRNA arm that is described in mmu-mir-741, suggesting that expression is conserved while the sequence has diverged.
[score:3]
rno-mir-741 is partially conserved; the syntenic mouse miRNA is mmu-mir-741.
[score:1]
The two miRNAs that were more prominent in BN-Lx, mir-742-3p and rno-mir-741-3p, reside in the same genomic cluster and may thus originate from the same primary transcript.
[score:1]
This may be one mechanism by which miRNAs evolve within this mir-463 cluster, in which the rno-mir-741/mmu-mir-741 ancestral miRNA has diverged between mouse and rat.
[score:1]
[1 to 20 of 5 sentences]
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| 3 |
Other miRNAs from this paper: rno-let-7e, rno-mir-21, rno-mir-34b, rno-mir-34c, rno-mir-34a, rno-mir-135a, rno-mir-187, rno-mir-192, rno-mir-194-1, rno-mir-194-2, rno-mir-449a, rno-mir-450a, rno-mir-383, rno-mir-542-1, rno-mir-378a, rno-mir-880, rno-mir-881, rno-mir-182, rno-mir-375, rno-mir-511, rno-mir-378b, rno-mir-542-2, rno-mir-542-3
rno-miR-881, rno-miR-880, miR-741-3p, miR-511*, miR-187, miR-449a, as well as 6 members of miR-34 family, miR-34a, miR-34a*, miR-34b, miR-34b*, miR-34c, and miR-34c*, showed over 10-fold up-regulation.
[score:4]
[1 to 20 of 1 sentences]
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