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17 publications mentioning hsa-mir-765

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-765. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 52
• In the module of miR-765 and miR-210, besides the validation of miR-765 and its target mRNAs above, miR-210 was upregulated in HBV-producing HepG2.2.15 cells compared to parental HepG2 cells, and identified to suppress hepatitis B virus [38]. [score:7]
Tumor suppressor QKI (the common target of miR-493-3p, miR-129 and miR-765) is expressed at significantly low levels in most of the gastric cancer tissues [46]. [score:7]
ANKRD12, a target of miR-765, is validated to be associated with chronic liver disease by existing works. [score:5]
In this module, miR-765 targets 6 mRNAs and miR-129 regulates 4 mRNAs. [score:4]
We also closely examined a strong negative regulatory relationship, shown in Figure 6. This regulatory relationship is between QKI mRNA and multiple miRNAs miR-493-3p, miR-129 and miR-765 (see Figure 9). [score:3]
Figure 7 The positive expression relationship between GFRA2 mRNA and miR-557, miR-765, and miR-17-3p. [score:3]
The number of nucleotide in the miRNA seed region is 7. The transition matrix is shown as in Table 6. The complementary probability of the sequence matching between the seed region of the three miRNAs (miR-557, miR-765 and miR-17-3p) and the 5' UTRs of GFRA2 are 1.337e-05, 1.488e-04, and 1.133e-04 respectively which all imply a strong indication of a functional target. [score:3]
As can be seen from Table 5, GFRA2 has a clear positive relationship with the expression of all of miR-557, miR-765 and miR-17-3p with Pearson's correlation coefficients 0.18, 0.21, and 0.26 respectively. [score:3]
For example, mRNA GFRA2 is positively regulated by multiple miRNAs miR-557, miR-765 and miR-17-3p which all likely bind at the 5' UTR end of GFRA2. [score:2]
Meanwhile, mRNA ANKRD12 of miR-765 is involved in one of the important roles of host miRNAs in regulating the liver-specific HCV [37]. [score:2]
• In the module of miR-129 and miR-765 (Figure 5), miR-129 has been strongly believed to be involved in the significant dysregulation in hepatocellular carcinogenesis [26, 35], and miR-765 is one of promising candidate miRNA biomarkers to detect hepatocellular carcinoma among hepatitis C virus patients [36]. [score:2]
Figure 5 The regulatory module inferred from the first HCV- rule consisting of miR-129 and miR-765. [score:2]
In particular, it was revealed that GFRA2 is positively regulated by miR-557, miR-765 and miR-17-3p that probably bind at different locations of the 5' UTR of this mRNA. [score:2]
Six miRNAs (miR-214, miR-34a, miR-129, miR-765 and miR-210) and 9 mRNAs (ACVR1C, RAB43, FNDC5, WDR33, ALDH4A1, ANKRD12, KCTD9, ARMC1 and DICER1) all in red are confirmed by literature work. [score:1]
GFRA2 QKI MAP2 FRMPD4 BNC2 CAMK2D miR-493-3p - -0.68 - 0.12 - - miR-184 - - - -0.05 - - miR-129 - -0.71 - - - 0.01 miR-214 - - -0.15 - -0.01 0.03 miR-557 0.18 - -0.01 - - - miR-765 0.21 -0.44 -0.02 -0.04 -0.10 - miR-17-3p 0.26 - - - -0.13 -0.13 miR-34a - - -0.05 - - - (Figure 8). [score:1]
An negative relationship between the QKI mRNA and miR-493-3p, miR-129, and miR-765. [score:1]
Independent of the research on GFRA2, miR-557 [26], miR-765 [36] and miR-17-3p [53] all have been reported to associate with hepatocellular carcinoma. [score:1]
The 5' UTRs of GFRA2 contains the seed sites of miR-557, miR-765 and miR-17-3p. [score:1]
In detail, the seed region of miR-557 matches the positions from 132 to 138 of GFRA2 5' UTRs, the seed region of miR-17-3p matches from 225 to 231, and the seed region of miR-765 matches from 495 to 502 (Figure 8). [score:1]
We attempted to verify whether the 5' UTR of GFRA2 has a full or partial complementary sequence pairing with the seed region of miR-557, miR-765 or miR-17-3p. [score:1]
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[+] score: 38
miR-765 regulates expression of the hairy and enhancer of split-1 (Hes1) gene, and stimulates NSC proliferation, and when this is overexpressed the expression of ki-67 and β-tubulin-III are increased while Glial fibrillary acidic protein (GFAP) expression is inhibited [72]. [score:12]
MiR-765 furthermore targets the 3′-UTR of Hes1 and decreases its expression in NSC, and an overexpression of Hes1 decreases miR-765 -induced proliferation of NSCs and inhibits neuronal differentiation [72]. [score:9]
MiR-765 is involved in various diseases [81, 82, 83, 84], can act as a tumour suppressor miRNA [82], and can also regulate arterial stiffness [83]. [score:6]
Li S. Zhao W. Xu Q. Yu Y. Yin C. MicroRNA-765 regulates neural stem cell proliferation and differentiation by modulating Hes1 expressionAm. [score:3]
Ali Sheikh M. S. Xia K. Li F. Deng X. Salma U. Deng H. Wei Wei L. Yang T. -L. Peng J. Circulating miR-765 and miR-149: Potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patientsBioMed Res. [score:3]
MiR-765 plays a major role in the development of the CNS and also regulates both the differentiation and proliferation of NSCs [77, 78, 79]. [score:2]
Liao Y. -C. Wang Y. -S. Hsi E. Chang M. -H. You Y. -Z. Juo S. -H. H. MicroRNA-765 influences arterial stiffness through modulating apelin expressionMol. [score:2]
Hsa-miR-765. [score:1]
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[+] score: 23
Other miRNAs from this paper: hsa-mir-188
mir-765 is reported inhibiting the phosphorylation of eNOS [65] and ERK/Akt/AMPK signalling by targeting the apelin [66], an endogenous ligand of G-protein. [score:5]
Our predictions report a potential link of mir-765 with 21 diseases, including neural disorders, cardiovascular diseases, rheumatoid, various lymphoma and carcinoma, leukaemia, liver cirrhosis and female reproductive system cancers (Fig.   5). [score:5]
Among them, mir-188 and mir-765 present the most of new predictions with diseases, and could be ubiquitous biomarkers of some diseases. [score:5]
mir-188 and mir-765 are predicted to play a role in several diseases. [score:3]
Among the 72 remaining putative associations, most of them imply mir-188 and mir-765 with several diseases (32 and 21 respectively) (Supplementary Table  S6). [score:3]
Mir-765 decreases the level of HMGA1 [68], a non-histone chromatin protein involved in the regulation of DNA -dependent 3R processes (replication, recombination and repair). [score:1]
Figure 5 Main biological processes and pathways known for mir-188 and mir-765. [score:1]
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[+] score: 22
Based on our bioinformatics prediction, mistletoe novel miRNAs might target critical neurotransmitter receptors and neurotransmitter transporters, such as gamma-aminobutyric acid type B receptor (GABA [B]) as a putative target of val-miR1086; glutamate metabotropic receptors (mGluRs) as putative targets of val-miR1342, val-miR954, val-miR550, val-miR560, val-miR765, val-miR1086, val-miR550, val-miR1328; dopamine transporter (DAT) as a putative target of val-miR765 and val-miR1110. [score:9]
Based on computational analysis, a range of key molecules in calcium signaling pathway (ko04020) were targeted by mistletoe miRNAs, for example, calcium voltage-gated channels (CaV1, CaV2 and CaV3) were mutual putative targets of val-miR1086 and val-miR765, calcineurin (CaN) was predicted to be target by val-miR765 and val-miR1110. [score:7]
Specifically, Toll-like receptors that are sentinel receptors of the host innate immune system to detect the presence of microbial infection [69], were predicted to be targeted by val-miR765 and val-miR1328. [score:3]
For example, runt related transcription factor 1 (RUNX1) and lysine methyltransferase 2A (MLL1) are essential for chromosomal translocations in acute myeloid leukemia [52, 53], which were predicted as targets of val-miR1086, val-miR765, val-miR615; and val-miR834 val-miR765, val-miR550, val-miR1127, val-miR954, val-miR1086, val-miR421, respectively. [score:3]
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[+] score: 15
Tested miRNAs (Table 1) included the 32 mentioned above; 6 additional miRNAs that appeared in more recent versions of the miRbase database and had putative target sites in the truncated isoform (miR-485-3p, miR-509, miR-617, miR-625, miR-765 and miR-768-5p) were also included because allelic variants were found in their target sites after re-sequencing of patients with anxiety disorders [19]. [score:5]
As for TR-NTRK3 (Figure 3C), a significant downregulation, ranging between 20% and 30%, was observed with miR-128, miR-485-3p, miR-765 and miR-768-5p; the strongest repression was caused by miR-128 (32% reduction) and miR-485-3p (30%). [score:4]
In fact, we identify one miRNAs regulating the full-length isoform of NTRK3 (miR-151-3p) and 4 miRNAs regulating the truncated isoform (miR-128, miR-485-3p, miR-765 and miR-768-5p). [score:3]
We identify one microRNA (miR-151-3p) that represses the full-length isoform of NTRK3 and four microRNAs (miR-128, miR-485-3p, miR-765 and miR-768-5p) that repress the truncated isoform. [score:1]
In the case of pGL4.13-TR, the luciferase activity was significantly reduced by 8 miRNAs (Figure 1A), all of which were predicted by at least one program: miR-128, miR-324-5p, miR-330, miR-485-3p, miR-509, miR-625, miR-765 and miR-768-5p. [score:1]
Luciferase-validated miRNAs were therefore transfected into either undifferentiated (miR-128, miR-324-5p, miR-330, miR-485-3p, miR-509, miR-625, miR-765 and miR-768-5p) or differentiated SH-SY5Y cells (miR-151-3p and miR-185), and protein levels were assessed by western blotting 72 h after transfection. [score:1]
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[+] score: 7
miR-184, miR-524-5p, miR-629, and miR-766 were upregulated, while miR-124, miR-222, miR-32, miR-744, and miR-765 were downregulated [28]. [score:7]
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[+] score: 6
detected the expression profile of miRNAs from blood samples of influenza A H1N1 virus-infected patients and then exhibited that the expression levels of 193 miRNA molecules were altered in all influenza patients, of which 16 highly dysregulated miRNAs (miR-1260, miR-1285, miR-18a, miR-185*, miR-299-5p, miR-26a, miR-30a, miR-335*, miR-34b, miR-519e, miR-576-3p, miR-628-3p, miR-664, miR-665, miR-765 and miR-767-5p) were able to provide a clear distinction between infected and healthy individuals [39]. [score:6]
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[+] score: 6
miR-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma [22]. [score:6]
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[+] score: 5
Results showed that miR-323b-5p, miR-221-3p, miR-524-5p, and miR-188-3p were underexpressed in albuminuric relative to nonalbuminuric patients, while miR-214-3p, miR-92b-5p, hsa-miR-765, hsa-miR-429, miR-373-5p, miR-1913, and miR-638 were overexpressed [71]. [score:5]
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[+] score: 4
Other miRNAs from this paper: hsa-mir-34a, hsa-mir-193a, hsa-mir-193b, hsa-mir-602
Surprisingly, we observed that three of the top ten most highly-regulated miRs, miR-193a-5p, miR-602, and miR-765, were predicted to target the p73 3'UTR [14]. [score:4]
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[+] score: 4
In contrast, miR-765, -34b, -519e, -18a, -628-3p, -185*, -576-3p, -519d, -28-5p, -26a, -1285, -665 and -30a were the 13 most down-regulated miRNAs in H1N1 patients. [score:4]
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[+] score: 3
Two miRNAs, namely miR-135 and miR-765 were higher expressed in both cell lines upon GEN treatment [77]. [score:3]
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[+] score: 3
Namely, miR-765, miR-622, and miR-1300 had significantly lower expression levels in female HCC than in male HCC (Table  2). [score:3]
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[+] score: 2
06 hsa-miR-595 5.29 hsa-miR-92b −9.97 hsa-miR-601 5.88 hsa-miR-765 4.47 hsa-miR-98 5.05 hsa-miR-99a 6.41 TGF-β -treated hsa-miR-20b −1.29 hsa-let-7a 1.38 hsa-miR-221 −1.25 hsa-let-7d 1.43 hsa-miR-605 −4.64 hsa-let-7e 2 hsa-miR-638 −1.40 hsa-miR-125a-5p 2.87 hsa-miR-663 −2.06 hsa-miR-146a 2.72 hsa-miR-720 −2.40 hsa-miR-21 1.14 hsa-miR-23a 1.20 hsa-miR-23b 1.14 hsa-miR-30c 1.89 hsa-miR-483-5p 1.38 hsa-miR-574-5p 2.23 hsa-miR-99b 1.63 10.1371/journal. [score:1]
06 hsa-miR-595 5.29 hsa-miR-92b −9.97 hsa-miR-601 5.88 hsa-miR-765 4.47 hsa-miR-98 5.05 hsa-miR-99a 6.41 TGF-β -treated hsa-miR-20b −1.29 hsa-let-7a 1.38 hsa-miR-221 −1.25 hsa-let-7d 1.43 hsa-miR-605 −4.64 hsa-let-7e 2 hsa-miR-638 −1.40 hsa-miR-125a-5p 2.87 hsa-miR-663 −2.06 hsa-miR-146a 2.72 hsa-miR-720 −2.40 hsa-miR-21 1.14 hsa-miR-23a 1.20 hsa-miR-23b 1.14 hsa-miR-30c 1.89 hsa-miR-483-5p 1.38 hsa-miR-574-5p 2.23 hsa-miR-99b 1.63 10.1371/journal. [score:1]
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[+] score: 1
A more distinct pattern of demarcation in miRNA profiles between these two set of cell types is observed in the region of the heat map depicting miR-1275 to miR-765 (Fig. 3). [score:1]
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[+] score: 1
P1) 8-mer 8th hsa-miR-485-3p NTRK3 19370765 rs72481816 15: 88521572 G C NA 8-mer 8th hsa-miR-765 NTRK3 19370765 rs72481814 15: 88522372 T C NA 7-8mer 4th hsa-miR-509-3p NTRK3 19370765 rs28574753 16: 28109760 G A. [score:1]
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[+] score: 1
In accordance with these previous histological data, the importance of NGF signaling in melanocyte biology [7], and its proved involvement in oncogenic pathways [4, 5], TrkA gene seems the most promising candidate for driving segmental amplification of the 1q23.1 region in MM, although we cannot exclude the possibility that the other genes (INSRR, PEAR1, LRRC71, MIR765, ARHGEF11, ETV3L, ETV3) within the 1q23.1 minimal common amplification could also participate in melanomagenesis. [score:1]
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