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21 publications mentioning hsa-mir-498

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-498. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 31
Since COL1A1 is one of the targets, upregulation of hsa-miR-498 could be one of the reasons for the downregulation of collagen type 1 and alteration in the collagen type 1 to collagen type 3 ratio. [score:9]
Hypoxia and ischemia in the tendon might have induced miR-498 which downregulated collagen type 1 expression but, additional studies are required to validate this aspect. [score:6]
The microRNA hsa-miR-498 was found to be upregulated in this study and it had twelve target genes which include HDAC1, HDAC2, COL1A1, and JUN. [score:6]
In addition, miRNA-498 was found to be upregulated to control the metastasis of several cancer types including liver cancer, adenocarcinoma and retinoblastoma [45]. [score:4]
Hypoxia contributes to the triggering of the expression of miR-498 in cancer microenvironment [43]. [score:3]
Also, increased expression of miR-498 has been correlated with the ECM damage associated with psoriasis [46]. [score:3]
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[+] score: 18
Other miRNAs from this paper: hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-21, hsa-mir-202
This was supported by independent studies in ovarian, endometrial and breast cancer cells where VD3 was shown to repress hTERT expression through the induction of miR-498, which in turn targets the 3’ untranslated region (3’ UTR) of hTERT transcripts and thus decreases its expression [120, 223]. [score:9]
Treatment of breast cancer cells with indole-3-carbonol (I3C) [121], colon cancer cells with 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) [84], ovarian cancer cells with miR-498 [120], and breast and endometrial cancer cells with progesterone [122], were reported to result in the suppression of ER -induced activation of hTERT expression. [score:5]
Kasiappan R. Shen Z. Tse A. K. Jinwal U. Tang J. Lungchukiet P. Sun Y. Kruk P. Nicosia S. V. Zhang X. 1,25-Dihydroxyvitamin d3 suppresses telomerase expression and human cancer growth through microrna-498 J. Biol. [score:4]
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[+] score: 13
Predicted targets for the top 5 annotated miRNA in exosomes (miR-663, miR-503, miR-492, miR-498 and miR-671–5p) were searched using TargetScan and subsequently the target mRNAs were analysed by IPA software to determine predicted canonical pathways, networks and biofunctions regulated by the exosomal miRNAs (Fig. 5 and Additional Information, Table S6. [score:8]
TargetScanHuman 5.1 was applied to predict mRNA targets for the top 5 annotated microRNAs detected in exosomes (miR-663, miR-503, miR-492, miR-498 and miR-671–5p), which generated a list of 500 mRNA. [score:5]
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[+] score: 11
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-21, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-30a, hsa-mir-31, hsa-mir-98, hsa-mir-99a, hsa-mir-101-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-197, hsa-mir-199a-1, hsa-mir-208a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-187, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-203a, hsa-mir-211, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-138-2, hsa-mir-140, hsa-mir-142, hsa-mir-143, hsa-mir-144, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-138-1, hsa-mir-146a, hsa-mir-200c, hsa-mir-155, hsa-mir-128-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-101-2, hsa-mir-219a-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-99b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-375, hsa-mir-328, hsa-mir-337, hsa-mir-338, hsa-mir-339, hsa-mir-384, hsa-mir-424, hsa-mir-429, hsa-mir-449a, hsa-mir-485, hsa-mir-146b, hsa-mir-494, hsa-mir-497, hsa-mir-520a, hsa-mir-518f, hsa-mir-499a, hsa-mir-509-1, hsa-mir-574, hsa-mir-582, hsa-mir-606, hsa-mir-629, hsa-mir-449b, hsa-mir-449c, hsa-mir-509-2, hsa-mir-874, hsa-mir-744, hsa-mir-208b, hsa-mir-509-3, hsa-mir-1246, hsa-mir-1248, hsa-mir-219b, hsa-mir-203b, hsa-mir-499b
Selected miRNAs were also analyzed in nasal biopsies from asthmatic patients and healthy donors, revealing differential expression of 10 miRNAs (miR-18a, miR-126, let-7e, miR-155, miR-224 were down-regulated, while miR-498, miR-197, miR-874, miR-143, miR-886-3p were up-regulated) [25]. [score:9]
Analysis of patients with asthma and allergic rhinitis showed further alterations in expression for six miRNAs: miR-224, miR-498, miR-187, miR-874, miR-143, miR-886-3p as compared to the control subjects. [score:2]
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[+] score: 11
Interestingly vitamin D3 has been reported to inhibit leptin -mediated cancer growth by upregulating miR-498, which downregulates leptin-enhanced expression of mRNA encoding telomerase reverse transcriptase (hTERT) [46]. [score:11]
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[+] score: 10
For instance, 1,25D [3] induces the synthesis of miR-498 through a functional VDRE located in the 5′ regulatory region, which leads to the down-regulation of telomerase and inhibition of ovarian cancer cell proliferation [34]. [score:7]
1,25D [3] induces miR-498 and results in the suppression of human telomerase reverse transcriptase in ovarian cancer cells [34]. [score:3]
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[+] score: 10
In esophageal cancers cell line KYSE150, as shown in the up panel of Figure 2A, over -expression of MIR30e, MIR363, MIR498, MIR196, MIR422, MIR337 or MIR202 remarkably increase the LC3-I to LC3-II conversion whereas miR-20b modestly decrease. [score:3]
Collectively, above results suggested that the four predicted miRNAs, MIR20b, MIR30e, MIR498 and MIR196 may be involved in the apoptotic pathway in esophageal cancers cells. [score:1]
In addition to LC3, the sequestosome 1(SQSTM1/P62) protein were accumulated when MIR30e, MIR363, MIR498 or MIR196 were transfected whereas MIR20b significantly decreased (up panel of Figure 2B). [score:1]
The cleaved PARP were modestly but significantly increased when transfection of MIR20b, MIR30e, MIR498 or MIR196 in both cell lines (Figure 2B). [score:1]
Follow-up experiments indicated transfection of MIR20b, MIR30e, MIR498 and MIR196 affected the apoptotic pathway in esophageal cancers cells. [score:1]
Interestingly, three out of the four apoptotic related miRNAs (MIR20b, MIR498 and MIR196), can modulate both autophagy and apoptosis processes. [score:1]
In another esophageal cancers cell line TE3, transfection of MIR20b, MIR363, MIR498 or MIR196 affected the autophagy when monitoring both LC3 and p62 (down panel of Figure 2A and Figure 2B). [score:1]
The results indicated at least 3 miRNAs (MIR20b, MIR498 and MIR196) were involved in cell death in two esophageal cancers cell lines. [score:1]
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[+] score: 8
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-23a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-196a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-218-1, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-30b, hsa-mir-128-1, hsa-mir-145, hsa-mir-191, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-30c-1, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-361, hsa-mir-337, hsa-mir-148b, hsa-mir-196b, hsa-mir-425, hsa-mir-20b, hsa-mir-486-1, hsa-mir-488, hsa-mir-181d, hsa-mir-519c, hsa-mir-520a, hsa-mir-526b, hsa-mir-520d, hsa-mir-506, hsa-mir-92b, hsa-mir-608, hsa-mir-617, hsa-mir-625, hsa-mir-641, hsa-mir-1264, hsa-mir-1271, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-21, bta-mir-30d, bta-mir-128-1, bta-mir-145, bta-mir-181a-2, bta-mir-30b, bta-mir-181b-2, bta-mir-20b, bta-mir-30e, bta-mir-92a-2, bta-let-7d, bta-mir-148b, bta-mir-181c, bta-mir-191, bta-mir-210, bta-mir-23a, bta-mir-361, bta-mir-425, bta-let-7g, bta-mir-30a, bta-let-7a-1, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-mir-23b, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-99b, hsa-mir-890, hsa-mir-888, hsa-mir-889, hsa-mir-938, hsa-mir-1184-1, hsa-mir-1203, hsa-mir-1204, hsa-mir-1265, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-128-2, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-218-1, bta-mir-296, bta-mir-30f, bta-mir-486, bta-mir-488, bta-mir-92a-1, bta-mir-92b, bta-mir-1271, bta-mir-181a-1, bta-mir-181b-1, bta-mir-148c, hsa-mir-1184-2, hsa-mir-1184-3, hsa-mir-486-2, bta-mir-1264, bta-mir-148d
For instance, miR-608 and miR-526b* were the top among the upregulated miRNAs while miR-1265, miR-196b, miR-498 and miR-1204 were the top among the downregulated miRNAs in CE animal group (Fig.   7). [score:7]
Among these, miR-938, miR-519c-3p, miR-1265, miR-498 and miR-488 were exclusively detected only in HE animals and 10 miRNAs including miR-608, miR-625*, miR-218-1*, miR-888*, miR-1184 and miR-1264 were detected only in SE and CE animal groups. [score:1]
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[+] score: 8
Kasiappan et al. [55] provided direct evidence for the involvement of a miRNA, miR-498, in the downregulation of hTERT through VDR. [score:5]
1α,25(OH) [2]VD [3] (100 nM) causes the formation of the VDR–RXR heterodimer and its binding to a VDRE located in the 5′ regulatory region of the miR-498 gene in OVCAR3 human ovarian cancer cell line. [score:2]
miR-498 binds to the complementary sequence in the 3′UTR of hTERT mRNA, thereby leading to its breakdown. [score:1]
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[+] score: 8
Other miRNAs from this paper: hsa-mir-29a, hsa-mir-512-1, hsa-mir-512-2, hsa-mir-532, hsa-mir-3064
Although a previous study has shown a direct interaction between hTERT mRNA and miR-498 in OC cells [17], the epigenetic mechanisms underlying hTERT upregulation in OC and tumor suppressor miRNAs involved in the regulation of hTERT in OC cells, are still not fully understood. [score:8]
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[+] score: 6
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-30a, hsa-mir-93, hsa-mir-96, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-205, hsa-mir-212, hsa-mir-181a-1, hsa-mir-222, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-132, hsa-mir-141, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-146a, hsa-mir-150, hsa-mir-184, hsa-mir-188, hsa-mir-320a, hsa-mir-181b-2, hsa-mir-30c-1, hsa-mir-302a, hsa-mir-34c, hsa-mir-30e, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-372, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-383, hsa-mir-339, hsa-mir-133b, hsa-mir-345, hsa-mir-425, hsa-mir-483, hsa-mir-146b, hsa-mir-202, hsa-mir-193b, hsa-mir-181d, hsa-mir-518f, hsa-mir-518b, hsa-mir-520c, hsa-mir-518c, hsa-mir-518e, hsa-mir-518a-1, hsa-mir-518d, hsa-mir-518a-2, hsa-mir-503, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-645, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-744, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-302e, hsa-mir-302f, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-320e, hsa-mir-548x, hsa-mir-378c, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
It has been shown that miR-498 induced by vitamin D3 decreases the mRNA expression of human telomerase reverse transcriptase [95]. [score:3]
The levels of miR-498 expression are decreased in malignant human ovarian tumors as well as in human ovarian cancer cell lines. [score:3]
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[+] score: 6
Schepeler and colleagues [103] showed that miR-320 or miR-498 expression was significantly associated with progression-free survival in stage II CRC. [score:3]
Recent studies on miRNAs have shown that the expression levels of different miRNAs, such as miR-21, miR-320, miR-498, miR-106a and miR-200c correlate with the probability of recurrence-free survival in CRC stage II-III. [score:3]
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[+] score: 5
Of the 20 candidate miRNAs evaluated, miR-498, and miR-150 were significantly up-regulated in AD frontal cortex; miR-150 was up-regulated in aMCI. [score:5]
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[+] score: 5
Kaplan-Meier survival curves showed that patients who had stage II CRC tumors with high expression of miR-320 or miR-498 had significantly shorter progression-free survival than did patients whose tumors showed low expression. [score:5]
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[+] score: 5
Moreover, the expression of miR-498, a member of C19MC, was reported in the fetal brain [49], echoing our report of Group C miRNAs being expressed in a fetal colon epithelium-derived cell line, CRL-1790 and placental Hs799. [score:5]
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[+] score: 4
Among them, miR-25*, -34b, -483-5p and miR-498 were found to be down-regulated in all cases. [score:4]
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[+] score: 4
Further, the identification of hPSC-enriched miR, such as the miR-498/515/519e cluster, also provides an interesting target for roles in pluripotency or differentiation. [score:3]
qPCR (e) and representative denaturing PAGE (12%) of the amplified products (f) of miR-302c, miR-367, miR-498, miR-515, miR-519e, miR-19b, miR-92a, miR-24-2, miR-126-3p, miR-126-5p, and miR-887. [score:1]
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[+] score: 3
Other miRNAs from this paper: hsa-mir-940
Myoma discs are used to compare the invasion of parental and transduced cell lines, such as MMP-8, endostatin, urokinase plasminogen activator receptor (uPAR) and trypsin-2 overexpressed, or cathepsin K, snail, miRNA-498 and miRNA-940 silenced carcinoma cell lines [39, 54, 68, 71, 75– 77]. [score:3]
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[+] score: 3
Additionally, two other cellular miRNAs were able to target RTA 3′UTR (i. e., hsa-miR-498 and hsa-miR-320d), promoting KSHV latency by repressing the RTA [195]. [score:3]
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[+] score: 2
Based on miRNAs profiling data, miR-20b, miR-498 and miR-196 were predicted to be involved in cell apoptosis and autophagy, which are shown to be key regulators of multiple cellular signaling pathways in esophageal cancer [42]. [score:2]
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[+] score: 1
Other miRNAs from this paper: hsa-mir-17, hsa-mir-93, hsa-mir-371a, hsa-mir-371b
Pre-miRNAs of C19MC are aligned (miR-498, 512-1,-2 and 515-1,-2 excluded). [score:1]
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