miRBase entry: hsa-let-7a-5p

Mature hsa-let-7a-5p

Accession MIMAT0000062
Description hsa-let-7a-5p mature miRNA
Hairpins
Sequence UGAGGUAGUAGGUUGUAUAGUU
Evidence experimental
cloned [1-3,5-8], Northern [1], Illumina [9]
Database links
Predicted targets


QuickGo Function

QuickGO is a fast web-based browser of the Gene Ontology and Gene Ontology annotation data.

Qualifier GO term Evidence Reference Annotation Extension
acts_upstream_of GO:0090051
negative regulation of cell migration involved in sprouting angiogenesis
ECO:0000314
direct assay evidence used in manual assertion
PMID:30467960 occurs_in
CL:0002543
enables GO:1903231
mRNA base-pairing translational repressor activity
ECO:0000314
direct assay evidence used in manual assertion
PMID:19878981 has_input
UniProtKB:P05231
enables GO:1903231
mRNA base-pairing translational repressor activity
ECO:0000314
direct assay evidence used in manual assertion
PMID:27809873 has_input
UniProtKB:P05231
enables GO:1903231
mRNA base-pairing translational repressor activity
ECO:0000314
direct assay evidence used in manual assertion
PMID:30467960 has_input
UniProtKB:Q03167
involved_in GO:0030512
negative regulation of transforming growth factor beta receptor signaling pathway
ECO:0000314
direct assay evidence used in manual assertion
PMID:30467960 occurs_in
CL:0002543
involved_in GO:0035195
miRNA-mediated post-transcriptional gene silencing
ECO:0000314
direct assay evidence used in manual assertion
PMID:19878981 has_input
UniProtKB:P05231
involved_in GO:0035195
miRNA-mediated post-transcriptional gene silencing
ECO:0000314
direct assay evidence used in manual assertion
PMID:27809873 has_input
UniProtKB:P05231
involved_in GO:0035278
miRNA-mediated gene silencing by inhibition of translation
ECO:0000314
direct assay evidence used in manual assertion
PMID:17671087
involved_in GO:0035279
miRNA-mediated gene silencing by mRNA destabilization
ECO:0000315
mutant phenotype evidence used in manual assertion
PMID:17671087
involved_in GO:0035279
miRNA-mediated gene silencing by mRNA destabilization
ECO:0000314
direct assay evidence used in manual assertion
PMID:30467960 has_input
UniProtKB:Q03167
involved_in GO:0070104
negative regulation of interleukin-6-mediated signaling pathway
ECO:0000314
direct assay evidence used in manual assertion
PMID:19878981
located_in GO:0005615
extracellular space
ECO:0007005
high throughput direct assay evidence used in manual assertion
PMID:18766170 part_of
UBERON:0001969
located_in GO:0005615
extracellular space
ECO:0007005
high throughput direct assay evidence used in manual assertion
PMID:26646931 part_of
UBERON:0001969
located_in GO:0070062
extracellular exosome
ECO:0000314
direct assay evidence used in manual assertion
PMID:31926946 produced_by
CL:0000235
located_in GO:1903561
extracellular vesicle
ECO:0007005
high throughput direct assay evidence used in manual assertion
PMID:28798470 produced_by
CL:0000182

StarBase

MicroRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data.

Target Gene ID Target Gene Name Number of supporting experiments Number of target-predicting programs Maximum number of target sites Chromosome Target-predicting region start Target-predicting region end Strand

miR2Disease

A manually curated database, aimed at providing a comprehensive resource of miRNA deregulation in various human diseases.

Click here for more information and to obtain references for the studies.

Disease Differential expression Experiment Year Study