Accession
MI0016777
Symbol
HGNC:
MIR4435-2
Description
Homo sapiens
hsa-mir-4435-2 precursor miRNA
Gene family
MIPF0001220;
mir-4435
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4435-2 is a long noncoding RNA (lncRNA) that is located on human chromosome 2q13 and is known as MIR4435-2 host gene (MIR4435-2HG) [PMC8054316]. It has been identified as an oncogenic lncRNA that is implicated in various tumors, including ovarian cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, and head and neck squamous cell carcinoma [PMC8054316]. MIR4435-2HG has been found to recruit miRNAs to participate in tumor progression [PMC9208505]. It has also been reported to promote lung cancer progression by activating β-catenin signaling [PMC6861872]. MIR4435-2, which is hosted by MIR4435-2HG, has been considered a biomarker in various cancers such as oral squamous cell carcinoma [PMC7655182]. The function of MIR4435-2 is still unknown [PMC6732945]. The lncRNA AWPPH on chromosome 2 serves as the host gene for MIR4435-2 [PMC6732945]. AWPPH and TGF-β1 may interact with each other through the mediation of MIR4435-2 [PMC6732945]. The lncRNA CYTOR on chromosome 2p11.1 overlaps with miR4435-1 and MIR44352. These three genes have been identified through association testing for their significance in certain diseases or conditions such as hepatocellular carcinoma and poor prognosis of tumors [PMC7443120]
Literature search
8 open access papers mention hsa-mir-4435-2
(56 sentences)
(56 sentences)
Sequence
226
reads,
12
reads per million, 22 experiments
gcaaAUGGCCAGAGCUCACACAGAGGgaugagugcacuucaccugcagugugacucagcaggccaacagaugcu
(((..(((((.(((.((((((...(((.((((.....)))))))...)))))))))....))))).....))).
(((..(((((.(((.((((((...(((.((((.....)))))))...)))))))))....))))).....))).
Structure
- ---aA ---A C AGA a u gca UGGCC GAG UCACAC GGg ugag g ||| ||||| ||| |||||| ||| |||| c cgu accgg cuc agugug ucc acuu a u agaca acga - acg - c
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr2: 111321013-111321086 [-]
Disease association
hsa-mir-4435-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4435
| Accession | MIMAT0018951 |
| Description | Homo sapiens hsa-miR-4435 mature miRNA |
| Sequence | 5 - AUGGCCAGAGCUCACACAGAGG - 26 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
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References
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