Accession
MI0014215
Symbol
HGNC:
MIR3180-2
Description
Homo sapiens
hsa-mir-3180-2 precursor miRNA
Gene family
MIPF0000894;
mir-3180
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR3180-2 is a long non-coding RNA (lncRNA) that is highly co-expressed with known Alzheimer's disease (AD)-related genes, such as S100B, AGT, and NTS [PMC7047416]. It has been found that MIR3180-2 and MIR3180-3 target protein-coding genes (PCGs) involved in the neuroprotective role of THOP1 in AD and blood vessel remodeling [PMC7047416]. Additionally, MIR3180-2 and MIR3180-3 share co-expressed PCGs with known AD-related PCGs, including VTI1A, CUX1, S100B, AGT, NTS, and IRAK4 [PMC7047416]. These findings suggest that MIR3180-2 may play a role in AD pathogenesis. Furthermore, MIR3180-2 is one of the top downregulated lncRNAs in AD [PMC7388310]. Co-expression network analysis has shown that MIR3180-2 is frequently co-expressed with relevant AD risk protein-coding genes [PMC8774680]. It's worth noting that disruptions in mir3180-1, MIR3180-2, and mir3180-3 have been observed along with their target genes CD44 and FAM115A in an individual from Tibet [PMC3938728]. These findings suggest that MIR31802 may have potential as a biomarker for AD.
Literature search
6 open access papers mention hsa-mir-3180-2
(60 sentences)
(60 sentences)
Sequence
4453
reads,
123
reads per million, 63 experiments
gcgacgggcggagCUUCCAGACGCUCCGCCCCACGUCGcaugcgccccgggaaagcgUGGGGCGGAGCUUCCGGAGGCCccgcccugc
(((..((((((.((((((.((.((((((((((((((....(.((...)).)...)))))))))))))).)).)))))).)))))))))
(((..((((((.((((((.((.((((((((((((((....(.((...)).)...)))))))))))))).)).)))))).)))))))))
Structure
ac a A C CGca g c gcg gggcgg gCUUCC GA GCUCCGCCCCACGU u cg ||| |||||| |||||| || |||||||||||||| | || c cgu cccgcc CGGAGG CU CGAGGCGGGGUgcg g gc -- C C U -aaa g c
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr16: 16309879-16309966 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-3180-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-3180-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-3180-5p
| Accession | MIMAT0015057 |
| Description | Homo sapiens hsa-miR-3180-5p mature miRNA |
| Sequence | 14 - CUUCCAGACGCUCCGCCCCACGUCG - 38 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-3180-3p
| Accession | MIMAT0015058 |
| Description | Homo sapiens hsa-miR-3180-3p mature miRNA |
| Sequence | 58 - UGGGGCGGAGCUUCCGGAGGCC - 79 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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