miRBase entry: hsa-mir-378b

Stem-loop hsa-mir-378b


Accession
MI0014154
Symbol
HGNC: MIR378B
Description
Homo sapiens hsa-mir-378b precursor miRNA
Gene family
MIPF0000168; mir-378

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR378B is a microRNA that has been implicated in various cellular processes. It has been shown that circ_0078710 enhances the expression of PRIM2 by sponging MIR378B, and the downregulation of circ_0078710 leads to an increase in MIR378B population, resulting in the downregulation of PRIM2, which is involved in cell proliferation [PMC9774417]. MIR378B has also been found to target Usp22, which is involved in the maintenance of neural stem/progenitor cells [PMC7041117]. In a study that functionally annotated miRNAs, MIR378B was identified as one of the miRNAs involved [PMC6349826]. Another study found that ANIT downregulated MIR378B in rat liver [PMC6349826]. Additionally, MIR378B was found to be upregulated in KSHV (+) tumors and was associated with miR143-3p [PMC8242244]. In a comparison between striatum and cortex tissues, MIR378B was one of the microRNAs that showed significant association with Q values [PMC5764268]. Furthermore, it was observed that MIR378B expression was elevated in CpG-stimulated DCs with miR-378b inhibition but showed no change with miR-378 overexpression [PMC6963666].

In summary, MIR378B is a microRNA that plays a role in cell proliferation and neural stem/progenitor cell maintenance. It has been implicated in various cellular processes and its expression can be regulated by different factors.

Literature search
193 open access papers mention hsa-mir-378b
(923 sentences)

Sequence

3698 reads, 37 reads per million, 50 experiments
ggucauugagucuucaaggcuaguggaaagagcACUGGACUUGGAGGCAGAAagacc
((((.((..(((((((((.((((((.......)))))).)))))))))..)).))))

Structure
    a  ga         g      ga 
gguc uu  gucuucaag cuagug  a
|||| ||  ||||||||| ||||||  a
ccag AA  CGGAGGUUC GGUCAc  g
    a  GA         A      ga 


Annotation confidence Not enough data
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Genome context
chr3: 10330229-10330285 [+]

Disease association
hsa-mir-378b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-378b

Accession MIMAT0014999
Description Homo sapiens hsa-miR-378b mature miRNA
Sequence 34 - ACUGGACUUGGAGGCAGAA - 52
Evidence experimental
Illumina [1]
Database links
Predicted targets

References

  1. PubMed ID: 20300190
    Characterization of the Melanoma miRNAome by Deep Sequencing
    "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
    "PLoS One (2010) 5:e9685