Accession
MI0006384
Symbol
HGNC:
MIR1249
Description
Homo sapiens
hsa-mir-1249 precursor miRNA
Gene family
MIPF0000667;
mir-1249
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1249 is one of the top up-regulated genes in the study [PMC9279949]. It has been validated in different time points [PMC6006352]. Down-regulation of Dicer leads to decreased production of MIR1249 [PMC3316564]. MIR1249 inhibition can increase chemo-sensitivity by limiting the expansion of chemo-refractory cancer stem cells (CSCs) [PMC7>PMC7590111]. MIR1249 is associated with the Wnt signaling pathway [PMC7590111]. MIR1249 expression is increased in response to chemotherapy treatment in human cholangiocarcinoma (CCA) cells [PMC7590111]. Inhibition of MIR1249 reduces the enrichment of CD133+ cells, while its enforced expression reduces sensitivity to chemotherapy [PMC7590111'>PMC7590111]. MIR1249 plays a role in driving the expansion of CSCs and is associated with worse prognosis independently of adjuvant chemotherapy in BTC patients [PMC7590111]. CD133+ BTC cells express higher levels of MIR1249 compared to CD133- cells, and its inhibition enhances BTC cell response to chemotherapy treatment [PMC7590111]. FZD8 is a potential target gene regulated by MIR1249, and its inhibition recapitulates the phenotype induced by MIR1249 mimic [PMC7590111].\n\nReferences:\n.\n\nReferences:\n- PMC9279949\n-n- PMC6006352\n-n- PMC3316564\n-n- PMC7
Literature search
16 open access papers mention hsa-mir-1249
(33 sentences)
(33 sentences)
Sequence
2157
reads,
67
reads per million, 118 experiments
gggAGGAGGGAGGAGAUGGGCCAAGUUcccucuggcuggaACGCCCUUCCCCCCCUUCUUCAccug
.(((((((((.((.((.((((...(((((........))))))))).)).))))))))))).....
.(((((((((.((.((.((((...(((((........))))))))).)).))))))))))).....
Structure
----g A A U CAA cuc
ggAGGAGGG GG GA GGGC GUUcc u
||||||||| || || |||| |||||
CUUCUUCCC CC CU CCCG CAagg g
guccA - C U --- ucg
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr22: 45200954-45201019 [-]
Disease association
hsa-mir-1249 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1249-3p
| Accession | MIMAT0005901 |
| Description | Homo sapiens hsa-miR-1249-3p mature miRNA |
| Sequence | 41 - ACGCCCUUCCCCCCCUUCUUCA - 62 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-1249-5p
| Accession | MIMAT0032029 |
| Description | Homo sapiens hsa-miR-1249-5p mature miRNA |
| Sequence | 4 - AGGAGGGAGGAGAUGGGCCAAGUU - 27 |
| Evidence | not_experimental |
| Database links |
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| Predicted targets |
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References
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