Accession
MI0006316
Symbol
HGNC:
MIR1227
Description
Homo sapiens
hsa-mir-1227 precursor miRNA
Gene family
MIPF0000454;
mir-1227
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-1227 is a differentially regulated miRNA that has been identified in various studies as a potential biomarker for prognosis, diagnosis, and treatment of liver diseases, articular cartilage conditions, and cancer recurrence [PMC7582243] [PMC3495209] [PMC5759858]. It has been found to be involved in the regulation of MECP2 expression and activity, epigenetic regulation of gene expression, degradation of the extracellular matrix, peroxisomal protein import [PMC7582243]. Hsa-mir-1227 has also been associated with metastatic behaviors in breast cancer and gastric cancer [PMC3495209]. Additionally, it has been shown to enhance migration of cancer-associated fibroblasts and is abundant in large oncosomes [PMC3495209]. Hsa-mir-1227 has been validated as a target for hsa-miR-10b and hsa-miR-146b-3p in different studies [PMC5759858]. Furthermore, it is one of the miRNAs that have shown significant correlation with recurrence in osteosarcoma [PMC5759858]. The predicted targets regulated by hsa-mir-1227 include a high number of transcription proteins as well as secretory, membrane, surface or receptor proteins [PMC3495209]. References: [PMC7582243] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582243/ [PMC3495209] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495209/ [PM5759858] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM5759858/
Literature search
11 open access papers mention hsa-mir-1227
(44 sentences)
(44 sentences)
Sequence
111
reads,
4
reads per million, 31 experiments
GUGGGGCCAGGCGGUGGugggcacugcuggggugggcacagcagccaugcagagcgggcauuugacccCGUGCCACCCUUUUCCCCAG
.(((((..(((.((((((.....((((..((.((.......)).))..)))).(((((........))))))))))))))..))))).
.(((((..(((.((((((.....((((..((.((.......)).))..)))).(((((........))))))))))))))..))))).
Structure
G CC C gggcacugcuggggugggcacagcagccaugcaga cau UGGGG AGG GGUGGu gcggg u ||||| ||| |||||| ||||| ACCCC UUC CCACCG UGCcc u G UU - ----------------------------------- cag
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 2234062-2234149 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-1227
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-1227 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1227-3p
| Accession | MIMAT0005580 |
| Description | Homo sapiens hsa-miR-1227-3p mature miRNA |
| Sequence | 69 - CGUGCCACCCUUUUCCCCAG - 88 |
| Evidence |
experimental
cloned [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-1227-5p
| Accession | MIMAT0022941 |
| Description | Homo sapiens hsa-miR-1227-5p mature miRNA |
| Sequence | 1 - GUGGGGCCAGGCGGUGG - 17 |
| Evidence | not_experimental |
References
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