Stem-loop hsa-mir-665

Accession

MI0005563

Symbol

HGNC: MIR665

Description

Homo sapiens hsa-mir-665 precursor miRNA

Gene family

MIPF0000404; mir-665

Literature search

18 open access papers mention hsa-mir-665
(36 sentences)

Sequence

533 reads, 26 reads per million, 64 experiments

ucuccucgaggggucucugccucuacccaggacucuuucaugACCAGGAGGCUGAGGCCCCUcacaggcggc
.(.(((.((((((((((.((((((...(((((....))).))....)))))).))))))))))..))).)..

Structure

-u u   -c          u      -acc  -   c 
  c ccu  gaggggucuc gccucu    ca gga u
  | |||  |||||||||| ||||||    || |||  
  g gga  cUCCCCGGAG CGGAGG    gu cuu c
cg c   ca          U      ACCA  a   u 

Annotation confidence Not enough data

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr14: 100875033-100875104 [+]

Clustered miRNAs

7 other miRNAs are < 10 kb from hsa-mir-665

Disease association

hsa-mir-665 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-665

• Accession: MIMAT0004952
• Description: Homo sapiens hsa-miR-665 mature miRNA
• Sequence: 43 - ACCAGGAGGCUGAGGCCCCU - 62
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298