Accession
MI0005116
Symbol
HGNC:
MIR765
Description
Homo sapiens
hsa-mir-765 precursor miRNA
Gene family
MIPF0000545;
mir-765
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR765 is a miRNA gene that has been found to be down-regulated in CNS tumor samples [PMC8235499]. It is one of five miRNAs, along with MIR149, MIR214, MIR574, and MIR595, that were consistently down-regulated across all CNS tumor samples [PMC8235499]. These miRNAs have been identified as potential diagnostic markers for CNS tumors [PMC8235499]. In addition to its role in CNS tumors, MIR765 has also been implicated in other types of cancer such as liver, prostate, and bone cancers [PMC8191793]. The downregulation of MIR765 has been shown to inhibit the proliferation, migration, and invasion of non-small cell lung cancer cells [PMC8349552]. Furthermore, MIR765 has been identified as a potential ceRNA (competitive endogenous RNA) for GALNT2 in IgA nephropathy (IgAN) [PMC7719294]. GALNT2 was found to be significantly down-regulated in the peripheral blood mononuclear cells (PBMCs) of IgAN patients and the identified circRNAs were shown to potentially manipulate the expression of GALNT2 through their interaction with MIR765 [PMC7719294]. Overall, these findings highlight the importance of MIR765 in various types of cancer and its potential as a diagnostic marker and therapeutic target.
Literature search
17 open access papers mention hsa-mir-765
(58 sentences)
(58 sentences)
Sequence
300
reads,
53
reads per million, 59 experiments
uuuaggcgcugaugaaaguggaguucaguagacagcccuuuucaagcccuacgagaaacugggguuucUGGAGGAGAAGGAAGGUGAUGaaggaucuguucucgugagccugaa
.((((((.((((.(((.......((((....((...(((((((((((((((........))))))))......)))))))...))..)))).......)))))).).)))))).
.((((((.((((.(((.......((((....((...(((((((((((((((........))))))))......)))))))...))..)))).......)))))).).)))))).
Structure
u g - u aguggag guag agc ------ cga uuaggc c uga gaa uuca ac ccuuuuc aagcccua g |||||| | ||| ||| |||| || ||||||| |||||||| aguccg g gcu cuu aaGU UG GGAAGAG uuuggggu a a a u - gucuagg --AG GAA GAGGUc caa
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr1: 156936131-156936244 [-]
Disease association
hsa-mir-765 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-765
| Accession | MIMAT0003945 |
| Description | Homo sapiens hsa-miR-765 mature miRNA |
| Sequence | 69 - UGGAGGAGAAGGAAGGUGAUG - 89 |
| Evidence |
experimental
cloned [1] |
| Database links |
|
| Predicted targets |
|
References
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