Stem-loop hsa-mir-503

Accession

MI0003188

Symbol

HGNC: MIR503

Description

Homo sapiens hsa-mir-503 precursor miRNA

Gene family

MIPF0000183; mir-503

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR503 is a microRNA that has been studied in the context of various diseases, including esophageal squamous cell carcinoma (ESCC) [PMC6694630]. In a study analyzing the gene expression profile of pHPL-ASC passage-specific genes, it was found that MIR503 was consistently downregulated in all passages (P1 to P5) [PMC6694630]. Furthermore, when comparing tumor samples from ESCC patients to adjacent non-tumorous tissues, a significant decrease in MIR503 expression was observed in 83% of the patients [PMC5487524]. This suggests that MIR503 may play a role in the development or progression of ESCC [PMC5487524]. Additionally, it has been noted that MIR503 is present in the 3' fragment of mir322 and may influence its fate [PMC4057207]. These findings highlight the potential importance of MIR503 as a biomarker or therapeutic target for ESCC [PMC6694630][PMC5487524][PMC4057207[PMC5487524][PMC4057207]. Further research is needed to elucidate its precise role and mechanisms of action in this context [PMC6694630][PMC5487524][PMC4057207[PMC5487524][PMC4057207].

Literature search

113 open access papers mention hsa-mir-503
(881 sentences)

Sequence

45931 reads, 405 reads per million, 115 experiments

ugcccUAGCAGCGGGAACAGUUCUGCAGugagcgaucggugcucuGGGGUAUUGUUUCCGCUGCCAGGgua
((((((.((((((((((((((.((.((..(((((.....))))))).)).)))))))))))))).))))))

Structure

      A              U  G  Gu     a 
ugcccU GCAGCGGGAACAGU CU CA  gagcg u
|||||| |||||||||||||| || ||  ||||| c
augGGA CGUCGCCUUUGUUA GG Gu  cucgu g
      C              U  G  --     g 

Annotation confidence High

Genome context

chrX: 134546328-134546398 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-503

Disease association

hsa-mir-503 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-503-5p

• Accession: MIMAT0002874
• Description: Homo sapiens hsa-miR-503-5p mature miRNA
• Sequence: 6 - UAGCAGCGGGAACAGUUCUGCAG - 28
• Evidence: experimental ; array-cloned [1], cloned [2-3], SOLiD [4]

Mature hsa-miR-503-3p

• Accession: MIMAT0022925
• Description: Homo sapiens hsa-miR-503-3p mature miRNA
• Sequence: 46 - GGGGUAUUGUUUCCGCUGCCAGG - 68
• Evidence: experimental ; SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


4. PubMed ID: 22282338
   Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
   "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
   "RNA (2012) 18:472-484