miRBase entry: hsa-mir-525

Stem-loop hsa-mir-525


Accession
MI0003152
Symbol
HGNC: MIR525
Description
Homo sapiens hsa-mir-525 precursor miRNA
Gene family
MIPF0000020; mir-515

Literature search
10 open access papers mention hsa-mir-525
(76 sentences)

Sequence

40 reads, 8 reads per million, 12 experiments
cucaagcugugacuCUCCAGAGGGAUGCACUUUCUcuuaugugaaaaaaaaGAAGGCGCUUCCCUUUAGAGCGuuacgguuuggg
(((((((((((((.(((.(((((((.((.((((((...............)))))).)).))))))).))).)))))))))))))

Structure
             u   C       U  A      cuuaug 
cucaagcugugac CUC AGAGGGA GC CUUUCU      u
||||||||||||| ||| ||||||| || ||||||      g
ggguuuggcauuG GAG UUUCCCU CG GGAAGa      a
             C   A       U  C      aaaaaa 


Annotation confidence Not enough data
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Comments
The mature products were previously named miR-525 and miR-525* in [1] and here. Landgraf et al. show that both products are significantly expressed, prompting a renaming to miR-525-5p and miR-525-3p [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr19: 53697533-53697617 [+]
Clustered miRNAs
10 other miRNAs are < 10 kb from hsa-mir-525
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-525 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-525-5p

Accession MIMAT0002838
Description Homo sapiens hsa-miR-525-5p mature miRNA
Sequence 15 - CUCCAGAGGGAUGCACUUUCU - 35
Evidence experimental
array-cloned [1], cloned [2]

Mature hsa-miR-525-3p

Accession MIMAT0002839
Description Homo sapiens hsa-miR-525-3p mature miRNA
Sequence 52 - GAAGGCGCUUCCCUUUAGAGCG - 73
Evidence experimental
array-cloned [1], cloned [2]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770