Stem-loop hsa-mir-491

Accession

MI0003126

Symbol

HGNC: MIR491

Description

Homo sapiens hsa-mir-491 precursor miRNA

Gene family

MIPF0000319; mir-491

Literature search

70 open access papers mention hsa-mir-491
(338 sentences)

Sequence

3762 reads, 67 reads per million, 106 experiments

uugacuuagcuggguAGUGGGGAACCCUUCCAUGAGGaguagaacacucCUUAUGCAAGAUUCCCUUCUACcuggcuggguugg
..(((((((((((((((.((((((..(((.((((((((((.....)))))))))).))).)))))).)))))))))))))))..

Structure

uu               U      CC   C          a 
  gacuuagcuggguAG GGGGAA  CUU CAUGAGGagu g
  ||||||||||||||| ||||||  ||| |||||||||| a
  uugggucggucCAUC UCCCUU  GAA GUAUUCcuca a
gg               U      -A   C          c 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr9: 20716105-20716188 [+]

Disease association

hsa-mir-491 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-491-5p

• Accession: MIMAT0002807
• Description: Homo sapiens hsa-miR-491-5p mature miRNA
• Sequence: 16 - AGUGGGGAACCCUUCCAUGAGG - 37
• Evidence: experimental ; array-cloned [1], cloned [2-3]

Mature hsa-miR-491-3p

• Accession: MIMAT0004765
• Description: Homo sapiens hsa-miR-491-3p mature miRNA
• Sequence: 50 - CUUAUGCAAGAUUCCCUUCUAC - 71
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770