miRBase entry: mml-mir-16-1

Stem-loop mml-mir-16-1


Accession
MI0002958
Description
Macaca mulatta mml-mir-16-1 precursor miRNA
Gene family
MIPF0000006; mir-15

Literature search
3 open access papers mention mml-mir-16-1
(4 sentences)

Sequence

68962 reads, 643 reads per million, 9 experiments
gucagcagugccuUAGCAGCACGUAAAUAUUGGCGuuaagauucuaaaauuaucuCCAGUAUUAACUGUGCUGCUGAAguaagguugac
((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..))))))

Structure
      ag   c          -  A        C u   gauu 
gucagc  ugc uUAGCAGCAC GU AAUAUUGG G uaa    c
||||||  ||| |||||||||| || |||||||| | |||     
caguug  aug AGUCGUCGUG CA UUAUGACC c auu    u
      ga   A          U  A        u u   aaaa 


Annotation confidence High
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Comments
Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context
chr17: 29400064-29400152 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from mml-mir-16-1
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mml-miR-16-5p

Accession MIMAT0002651
Description Macaca mulatta mml-miR-16-5p mature miRNA
Sequence 14 - UAGCAGCACGUAAAUAUUGGCG - 35
Evidence experimental
Illumina [2]
Database links
Predicted targets

Mature mml-miR-16-1-3p

Accession MIMAT0026594
Description Macaca mulatta mml-miR-16-1-3p mature miRNA
Sequence 56 - CCAGUAUUAACUGUGCUGCUGAA - 78
Evidence experimental
Illumina [3]

References

  1. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68

  2. PubMed ID: 15652478
    Phylogenetic shadowing and computational identification of human microRNA genes
    "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
    "Cell (2005) 120:21-24

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45