miRBase entry: hsa-mir-151a

Stem-loop hsa-mir-151a


Accession
MI0000809
Symbol
HGNC: MIR151A
Description
Homo sapiens hsa-mir-151a precursor miRNA
Gene family
MIPF0000057; mir-28

Literature search
102 open access papers mention hsa-mir-151a
(504 sentences)

Sequence

523953 reads, 3662 reads per million, 157 experiments
uuuccugcccUCGAGGAGCUCACAGUCUAGUaugucucauccccuaCUAGACUGAAGCUCCUUGAGGacagggauggucauacucaccuc
.((((((.((((((((((((..((((((((((.(........).)))))))))).)))))))))))).)))))).(((.......)))..

Structure
---------------u      c            CA          u ucu 
                uuccug ccUCGAGGAGCU  CAGUCUAGUa g   c
                |||||| ||||||||||||  |||||||||| |    
                agggac GGAGUUCCUCGA  GUCAGAUCau c   a
cuccacucauacuggu      a            -A          c ccu 


Annotation confidence Not enough data
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Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr8: 140732564-140732653 [-]

Disease association
hsa-mir-151a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-151a-5p

Accession MIMAT0004697
Description Homo sapiens hsa-miR-151a-5p mature miRNA
Sequence 11 - UCGAGGAGCUCACAGUCUAGU - 31
Evidence experimental
cloned [4-5]
Database links
Predicted targets

Mature hsa-miR-151a-3p

Accession MIMAT0000757
Description Homo sapiens hsa-miR-151a-3p mature miRNA
Sequence 47 - CUAGACUGAAGCUCCUUGAGG - 67
Evidence experimental
cloned [3-5], Northern [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  4. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  5. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365