miRBase entry: hsa-mir-378a

Stem-loop hsa-mir-378a


Accession
MI0000786
Symbol
HGNC: MIR378A
Description
Homo sapiens hsa-mir-378a precursor miRNA
Gene family
MIPF0000168; mir-378

Literature search
212 open access papers mention hsa-mir-378a
(1262 sentences)

Sequence

5214209 reads, 6859 reads per million, 154 experiments
agggCUCCUGACUCCAGGUCCUGUGUguuaccuagaaauagcACUGGACUUGGAGUCAGAAGGCcu
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))

Structure
   g  C              U    gu acc 
agg CU CUGACUCCAGGUCC GUGU  u   u
||| || |||||||||||||| ||||  |    
ucC GA GACUGAGGUUCAGG CAcg  a   a
   G  A              U    au aag 


Annotation confidence High
Do you think this miRNA is real?
Comments
miR-422b was the most abundant miRNA cloned from human promyelocytic leukemia (HL-60) cells [2]. The sequence originates from the opposite arm of the human homologue of previously identified mouse mir-378 [1]. Landgraf et al. show that the 3' product (previously called miR-422b) is the predominant one [3]. Further, mir-378 and mir-422a loci are unrelated. miR-422b is thus renamed miR-378 here.

Genome context
chr5: 149732825-149732890 [+]

Disease association
hsa-mir-378a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-378a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-378a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-378a-5p

Accession MIMAT0000731
Description Homo sapiens hsa-miR-378a-5p mature miRNA
Sequence 5 - CUCCUGACUCCAGGUCCUGUGU - 26
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-378a-3p

Accession MIMAT0000732
Description Homo sapiens hsa-miR-378a-3p mature miRNA
Sequence 43 - ACUGGACUUGGAGUCAGAAGGC - 64
Evidence experimental
cloned [2-3], Northern [2]
Database links
Predicted targets

References

  1. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230