Stem-loop sequence hsa-mir-376a-1

Accession

MI0000784 (change log)

Previous IDs

hsa-mir-376a

Symbol

HGNC:MIR376A1

Description

Homo sapiens miR-376a-1 stem-loop

Gene family

MIPF0000091; mir-368

Literature search

80 open access papers mention hsa-mir-376a-1
(398 sentences)

Stem-loop

   u    g  a    c    u      --gua   u 
5'  aaaa gu gauu uccu cuauga     cau a
    |||| || |||| |||| ||||||     ||| u
3'  uuuu ca cuaa agga gauacu     gua u
   c    g  c    a    -      aauua   u 

Deep sequencing

25053 reads, 120 reads per million, 132 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature miR-376a products have been shown to be modified by A to I edits [3].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr14: 101040782-101040849 [+]
• Overlapping transcripts:

  antisense

  OTTHUMT00000414335 ; BEGAIN-006; intron 1

  ENST00000554140 ; BEGAIN-006; intron 1

Clustered miRNAs

< 10kb from hsa-mir-376a-1

• hsa-mir-543: chr14: 101031987-101032064 [+]
• hsa-mir-495: chr14: 101033755-101033836 [+]
• hsa-mir-376c: chr14: 101039690-101039755 [+]
• hsa-mir-376a-2: chr14: 101040069-101040148 [+]
• hsa-mir-654: chr14: 101040219-101040299 [+]
• hsa-mir-376b: chr14: 101040436-101040535 [+]
• hsa-mir-376a-1: chr14: 101040782-101040849 [+]
• hsa-mir-300: chr14: 101041363-101041445 [+]
• hsa-mir-1185-1: chr14: 101042977-101043062 [+]
• hsa-mir-1185-2: chr14: 101044198-101044283 [+]
• hsa-mir-381: chr14: 101045920-101045994 [+]
• hsa-mir-487b: chr14: 101046455-101046538 [+]
• hsa-mir-539: chr14: 101047321-101047398 [+]
• hsa-mir-889: chr14: 101047901-101047979 [+]
• hsa-mir-544a: chr14: 101048658-101048748 [+]
• hsa-mir-655: chr14: 101049550-101049646 [+]

Database links

• EntrezGene:MIR376A1
• HGNC:MIR376A1
• RNAcentral:URS000075B4B1_9606
• miRBase Tracker:MI0000784

Mature sequence hsa-miR-376a-5p

• Accession: MIMAT0003386
• Previous IDs: hsa-miR-376a*
• Sequence: 7 - guagauucuccuucuaugagua - 28
• Deep sequencing: 5733 reads, 110 experiments
• Evidence: experimental; cloned [2,4]
• Database links:
  • RNAcentral:URS000032A93F_9606
• Predicted targets:
  • TargetMiner:hsa-miR-376a-5p
  • TargetScanVert:hsa-miR-376a-5p
  • miRDB:hsa-miR-376a-5p
  • microrna.org:hsa-miR-376a-5p

Mature sequence hsa-miR-376a-3p

• Accession: MIMAT0000729
• Previous IDs: hsa-miR-376a
• Sequence: 44 - aucauagaggaaaauccacgu - 64
• Deep sequencing: 38783 reads, 132 experiments
• Evidence: experimental; cloned [1,3], SOLiD [4]
• Database links:
  • RNAcentral:URS000041E11D_9606
• Predicted targets:
  • TargetMiner:hsa-miR-376a-3p
  • TargetScanVert:hsa-miR-376a-3p
  • miRDB:hsa-miR-376a-3p
  • microrna.org:hsa-miR-376a-3p

References

1. PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17322061 "Redirection of silencing targets by adenosine-to-inosine editing of miRNAs" Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K Science. 315:1137-1140(2007).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).