Accession
MI0000781
Symbol
HGNC:
MIR373
Description
Homo sapiens
hsa-mir-373 precursor miRNA
Gene family
MIPF0000500;
mir-373
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR373 is a microRNA that has been predicted by computational algorithms to regulate several proteins involved in the actin cytoskeleton, including twinfilin-1 and-2, thymosin, and profilin-2 [PMC7408560]. In a study evaluating breast cancer biomarkers, MIR373 was selected as a candidate and its expression levels were assessed in breast cancer patients and healthy individuals [PMC8182592]. Another study found that MIR373 was involved in a subpopulation of chemo-resistant circulating tumor cells (CTCs) with extensive aberrations and marked metastatic ability [PMC8466266]. Additionally, MIR373 levels were found to be upregulated in the substantia nigra of patients with Parkinson's disease, suggesting its involvement in α-synuclein clearance defects [PMC6627933]. These findings highlight the potential role of MIR373 as a regulator of actin cytoskeleton proteins, a biomarker for breast cancer, chemo-resistant CTCs, and Parkinson's disease pathology.
Literature search
151 open access papers mention hsa-mir-373
(849 sentences)
(849 sentences)
Sequence
134
reads,
28
reads per million, 21 experiments
gggauACUCAAAAUGGGGGCGCUUUCCuuuuugucuguacuggGAAGUGCUUCGAUUUUGGGGUGUccc
((((((((((((((.((((((((((((..............)))))))))))).))))).)))))))))
((((((((((((((.((((((((((((..............)))))))))))).))))).)))))))))
Structure
- G uuuuug
gggauACUC AAAAU GGGGCGCUUUCC u
||||||||| ||||| ||||||||||||
cccUGUGGG UUUUA CUUCGUGAAGgg c
G G ucaugu
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 53788705-53788773 [+]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-373
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-373 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-373-5p
| Accession | MIMAT0000725 |
| Description | Homo sapiens hsa-miR-373-5p mature miRNA |
| Sequence | 6 - ACUCAAAAUGGGGGCGCUUUCC - 27 |
| Evidence |
experimental
cloned [1] |
Mature hsa-miR-373-3p
| Accession | MIMAT0000726 |
| Description | Homo sapiens hsa-miR-373-3p mature miRNA |
| Sequence | 44 - GAAGUGCUUCGAUUUUGGGGUGU - 66 |
| Evidence |
experimental
cloned [1-2], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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