Stem-loop sequence hsa-mir-34c

Accession

MI0000743 (change log)

Symbol

HGNC:MIR34C

Description

Homo sapiens miR-34c stem-loop

Gene family

MIPF0000039; mir-34

Literature search

448 open access papers mention hsa-mir-34c
(2506 sentences)

Stem-loop

        ag     a   a    a     c      c  a 
5' agucu  uuacu ggc gugu guuag ugauug ua u
   |||||  ||||| ||| |||| ||||| |||||| ||  
3' uuaga  aaugg ccg caca caauc acuaac au a
        aa     a   g    c     -      c  g 

Deep sequencing

207792 reads, 380 reads per million, 137 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

Houbaviy et al. cloned 3 closely related sequences from mouse embryonic stem cells [1], and named them miR-34a, miR-34b and miR-172. These names have been remapped to miR-34c (MI0000403), miR-34b (MI0000404) and miR-34a (MI0000584) to clarify homology with human sequences.

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr11: 111513439-111513515 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000319352 ; SIK2-001; intron 3

  ENST00000304987 ; SIK2-001; intron 3

Clustered miRNAs

< 10kb from hsa-mir-34c

• hsa-mir-34b: chr11: 111512938-111513021 [+]
• hsa-mir-34c: chr11: 111513439-111513515 [+]

Database links

• EntrezGene:MIR34C
• HGNC:MIR34C
• RNAcentral:URS000075E7C8_9606
• miRBase Tracker:MI0000743

Mature sequence hsa-miR-34c-5p

• Accession: MIMAT0000686
• Previous IDs: hsa-miR-34c
• Sequence: 13 - aggcaguguaguuagcugauugc - 35
• Deep sequencing: 204545 reads, 131 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS00002C7B2B_9606
• Predicted targets:
  • TargetMiner:hsa-miR-34c-5p
  • TargetScanVert:hsa-miR-34c-5p
  • miRDB:hsa-miR-34c-5p
  • microrna.org:hsa-miR-34c-5p

Mature sequence hsa-miR-34c-3p

• Accession: MIMAT0004677
• Sequence: 46 - aaucacuaaccacacggccagg - 67
• Deep sequencing: 3247 reads, 122 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS00002C7C59_9606
• Predicted targets:
  • TargetMiner:hsa-miR-34c-3p
  • TargetScanVert:hsa-miR-34c-3p
  • miRDB:hsa-miR-34c-3p
  • microrna.org:hsa-miR-34c-3p

References

1. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).