miRBase entry: hsa-mir-138-1

Stem-loop hsa-mir-138-1


Accession
MI0000476
Symbol
HGNC: MIR138-1
Description
Homo sapiens hsa-mir-138-1 precursor miRNA
Gene family
MIPF0000075; mir-138

Literature search
228 open access papers mention hsa-mir-138-1
(1564 sentences)

Sequence

87543 reads, 800 reads per million, 83 experiments
cccuggcauggugugguggggcAGCUGGUGUUGUGAAUCAGGCCGuugccaaucagagaacgGCUACUUCACAACACCAGGGCCacaccacacuacagg
.((((...((((((((((.(((..(((((((((((((...(((((((..(.....)..)))))))..))))))))))))).))).))))))))))))))

Structure
c    gca          g   AG             UCA       gc a 
 ccug   ugguguggug ggc  CUGGUGUUGUGAA   GGCCGuu  c a
 ||||   |||||||||| |||  |||||||||||||   |||||||  | u
 ggac   aucacaccac CCG  GACCACAACACUU   UCGgcaa  g c
-    ---          a   -G             -CA       ga a 


Annotation confidence High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Expression in human was later validated by cloning [2].

Genome context
chr3: 44114212-44114310 [+]

Disease association
hsa-mir-138-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-138-5p

Accession MIMAT0000430
Description Homo sapiens hsa-miR-138-5p mature miRNA
Sequence 23 - AGCUGGUGUUGUGAAUCAGGCCG - 45
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-138-1-3p

Accession MIMAT0004607
Description Homo sapiens hsa-miR-138-1-3p mature miRNA
Sequence 63 - GCUACUUCACAACACCAGGGCC - 84
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043