Stem-loop sequence hsa-mir-125a

Accession

MI0000469 (change log)

Symbol

HGNC:MIR125A

Description

Homo sapiens miR-125a stem-loop

Gene family

MIPF0000033; mir-10

Literature search

389 open access papers mention hsa-mir-125a
(1709 sentences)

Stem-loop

   u     u u     uc  ug   c    ua        ----  a 
5'  gccag c cuagg  cc  aga ccuu  accuguga    gg c
    ||||| | |||||  ||  ||| ||||  ||||||||    ||  
3'  cgguc g ggucc  gg  ucu ggag  uggacacu    cc a
   c     u c     ga  gu   u    --        ggga  u 

Deep sequencing

1154935 reads, 3.99e+03 reads per million, 159 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr19: 51693254-51693339 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000465190 ; SIGLEC20P-001; intron 6

  ENST00000595243 ; SIGLEC20P-001; intron 6

Clustered miRNAs

< 10kb from hsa-mir-125a

• hsa-mir-99b: chr19: 51692612-51692681 [+]
• hsa-let-7e: chr19: 51692786-51692864 [+]
• hsa-mir-125a: chr19: 51693254-51693339 [+]

Database links

• EntrezGene:MIR125A
• HGNC:MIR125A
• RNAcentral:URS000075D168_9606
• miRBase Tracker:MI0000469

Mature sequence hsa-miR-125a-5p

• Accession: MIMAT0000443
• Previous IDs: hsa-miR-125a
• Sequence: 15 - ucccugagacccuuuaaccuguga - 38
• Deep sequencing: 1146942 reads, 159 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS00005A4DCF_9606
• Predicted targets:
  • TargetMiner:hsa-miR-125a-5p
  • TargetScanVert:hsa-miR-125a-5p
  • miRDB:hsa-miR-125a-5p
  • microrna.org:hsa-miR-125a-5p

Mature sequence hsa-miR-125a-3p

• Accession: MIMAT0004602
• Sequence: 53 - acaggugagguucuugggagcc - 74
• Deep sequencing: 7970 reads, 150 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS00001F0C23_9606
• Predicted targets:
  • TargetMiner:hsa-miR-125a-3p
  • TargetScanVert:hsa-miR-125a-3p
  • miRDB:hsa-miR-125a-3p
  • microrna.org:hsa-miR-125a-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).