Stem-loop sequence hsa-mir-141

Accession

MI0000457 (change log)

Symbol

HGNC:MIR141

Description

Homo sapiens miR-141 stem-loop

Gene family

MIPF0000019; mir-8

Literature search

359 open access papers mention hsa-mir-141
(1896 sentences)

Stem-loop

   c    g    u   -u       --    u        -   ugg  ua 
5'  ggcc gccc ggg  ccaucuu  ccag acaguguu gga   uc  a
    |||| |||| |||  |||||||  |||| |||||||| |||   ||  u
3'  uugg uggg ccc  gguagaa  gguc ugucacaa ccu   ag  u
   c    g    -   uc       au    -        u   cga  ug 

Deep sequencing

746410 reads, 1.7e+03 reads per million, 154 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-141 in human [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr12: 6964097-6964191 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000402982 ; USP5-001; intron 1

  OTTHUMT00000402983 ; USP5-002; intron 1

  OTTHUMT00000402984 ; USP5-003; intron 1

  ENST00000229268 ; USP5-001; intron 1

  ENST00000389231 ; USP5-002; intron 1

  ENST00000542087 ; USP5-003; intron 1

Clustered miRNAs

< 10kb from hsa-mir-141

• hsa-mir-200c: chr12: 6963699-6963766 [+]
• hsa-mir-141: chr12: 6964097-6964191 [+]

Database links

• EntrezGene:MIR141
• HGNC:MIR141
• RNAcentral:URS000075ECD7_9606
• miRBase Tracker:MI0000457

Mature sequence hsa-miR-141-5p

• Accession: MIMAT0004598
• Previous IDs: hsa-miR-141*
• Sequence: 17 - caucuuccaguacaguguugga - 38
• Deep sequencing: 5063 reads, 112 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS000055E199_9606
• Predicted targets:
  • TargetMiner:hsa-miR-141-5p
  • TargetScanVert:hsa-miR-141-5p
  • miRDB:hsa-miR-141-5p
  • microrna.org:hsa-miR-141-5p

Mature sequence hsa-miR-141-3p

• Accession: MIMAT0000432
• Previous IDs: hsa-miR-141
• Sequence: 59 - uaacacugucugguaaagaugg - 80
• Deep sequencing: 741123 reads, 153 experiments
• Evidence: experimental; cloned [2-4]
• Database links:
  • RNAcentral:URS000003E1A9_9606
• Predicted targets:
  • TargetMiner:hsa-miR-141-3p
  • TargetScanVert:hsa-miR-141-3p
  • miRDB:hsa-miR-141-3p
  • microrna.org:hsa-miR-141-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).