miRBase entry: hsa-mir-141

Stem-loop hsa-mir-141


Accession
MI0000457
Symbol
HGNC: MIR141
Description
Homo sapiens hsa-mir-141 precursor miRNA
Gene family
MIPF0000019; mir-8

Literature search
359 open access papers mention hsa-mir-141
(1909 sentences)

Sequence

93091 reads, 931 reads per million, 140 experiments
cggccggcccugggucCAUCUUCCAGUACAGUGUUGGAuggucuaauugugaagcuccUAACACUGUCUGGUAAAGAUGGcucccggguggguuc
.((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).)))).

Structure
c    g    u   -u       --    U        -   ugg  ua 
 ggcc gccc ggg  cCAUCUU  CCAG ACAGUGUU GGA   uc  a
 |||| |||| |||  |||||||  |||| |||||||| |||   ||  u
 uugg uggg ccc  GGUAGAA  GGUC UGUCACAA ccu   ag  u
c    g    -   uc       AU    -        U   cga  ug 


Annotation confidence High
Do you think this miRNA is real?
Comments
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-141 in human [2].

Genome context
chr12: 6964097-6964191 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-141
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-141 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-141-5p

Accession MIMAT0004598
Description Homo sapiens hsa-miR-141-5p mature miRNA
Sequence 17 - CAUCUUCCAGUACAGUGUUGGA - 38
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-141-3p

Accession MIMAT0000432
Description Homo sapiens hsa-miR-141-3p mature miRNA
Sequence 59 - UAACACUGUCUGGUAAAGAUGG - 80
Evidence experimental
cloned [2-4]
Database links
Predicted targets

References

  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739