Accession
MI0000454
Symbol
HGNC:
MIR137
Description
Homo sapiens
hsa-mir-137 precursor miRNA
Gene family
MIPF0000106;
mir-137
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR137 is a gene that has been studied in relation to various diseases, including non-small-cell lung cancer [PMC4626561]. In a study, it was found that the methylation of MIR137 gene was correlated with the progression of non-small-cell lung cancer [PMC4626561]. Additionally, in another study, it was observed that the maximum peak outward potassium amplitude of VU0240551-treated MIR137 cKO neurons was adjusted to a similar level as wild-type neurons [PMC7237267]. These findings suggest that MIR137 may play a role in regulating potassium channels and neuronal activity. Further research is needed to fully understand the mechanisms and implications of MIR137 in disease progression and neuronal function.
Literature search
199 open access papers mention hsa-mir-137
(1747 sentences)
(1747 sentences)
Sequence
102896
reads,
1706
reads per million, 71 experiments
gguccucugacucucuucggugACGGGUAUUCUUGGGUGGAUAAUacggauuacguugUUAUUGCUUAAGAAUACGCGUAGucgaggagaguaccagcggca
.(.((.((((((((((((((..(((.(((((((((((((.((((((((.....)).))))))))))))))))))).)))..)))))))))))..))).))).
.(.((.((((((((((((((..(((.(((((((((((((.((((((((.....)).))))))))))))))))))).)))..)))))))))))..))).))).
Structure
g u u -- ug G G - g g cc cug acucucuucgg ACG GUAUUCUUGGGUG AUAAUa cg a | || ||| ||||||||||| ||| ||||||||||||| |||||| || u c gg gac ugagaggagcu UGC CAUAAGAAUUCGU UAUUgu gc u a - c ca GA G - u a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].
Genome context
chr1: 98046070-98046171 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-137
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-137 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-137 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-137 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-137-3p
| Accession | MIMAT0000429 |
| Description | Homo sapiens hsa-miR-137-3p mature miRNA |
| Sequence | 59 - UUAUUGCUUAAGAAUACGCGUAG - 81 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-137-5p
| Accession | MIMAT0037310 |
| Description | Homo sapiens hsa-miR-137-5p mature miRNA |
| Sequence | 23 - ACGGGUAUUCUUGGGUGGAUAAU - 45 |
| Evidence | not_experimental |
References
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