miRBase entry: hsa-let-7i

Stem-loop hsa-let-7i


Accession
MI0000434
Symbol
HGNC: MIRLET7I
Description
Homo sapiens hsa-let-7i precursor miRNA
Gene family
MIPF0000002; let-7

Literature search
1093 open access papers mention hsa-let-7i
(6021 sentences)

Sequence

1571183 reads, 7403 reads per million, 138 experiments
cuggcUGAGGUAGUAGUUUGUGCUGUUggucggguugugacauugcccgcuguggagauaaCUGCGCAAGCUACUGCCUUGCUa
.((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))

Structure
c    U                 U   --------  u     ugu 
 uggc GAGGUAGUAGUUUGUGC GUU        gg cgggu   g
 |||| ||||||||||||||||| |||        || |||||   a
 aUCG UUCCGUCAUCGAACGCG Caa        uc gcccg   c
-    -                 U   uagaggug  -     uua 


Annotation confidence High
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Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
chr12: 62603686-62603769 [+]

Disease association
hsa-let-7i is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-let-7i-5p

Accession MIMAT0000415
Description Homo sapiens hsa-let-7i-5p mature miRNA
Sequence 6 - UGAGGUAGUAGUUUGUGCUGUU - 27
Evidence experimental
cloned [2-3], Illumina [5]
Database links
Predicted targets

Mature hsa-let-7i-3p

Accession MIMAT0004585
Description Homo sapiens hsa-let-7i-3p mature miRNA
Sequence 62 - CUGCGCAAGCUACUGCCUUGCU - 83
Evidence experimental
cloned [2-4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 17989717
    Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
    "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
    "Leukemia (2008) 22:330-338

  4. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739