miRBase entry: hsa-mir-181c

Stem-loop hsa-mir-181c


Accession
MI0000271
Symbol
HGNC: MIR181C
Description
Homo sapiens hsa-mir-181c precursor miRNA
Gene family
MIPF0000007; mir-181

Literature search
279 open access papers mention hsa-mir-181c
(1258 sentences)

Sequence

25356 reads, 322 reads per million, 130 experiments
cggaaaauuugccaaggguuugggggAACAUUCAACCUGUCGGUGAGUuugggcagcucaggcaAACCAUCGACCGUUGAGUGGACccugaggccuggaauugccauccu
.(((.......(((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).))))))))........))).

Structure
c   -aaauuug   ag     g    AA        CU       A     ggca 
 gga        cca  gguuu gggg  CAUUCAAC  GUCGGUG GUuug    g
 |||        |||  ||||| ||||  ||||||||  ||||||| |||||    c
 ccu        ggu  ccgga uccC  GUGAGUUG  CAGCUAC CAAac    u
u   accguuaa   --     g    AG        -C       -     ggac 


Annotation confidence High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm the expression of miR-181c in human [2].

Genome context
chr19: 13874699-13874808 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181c
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-181c is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-181c is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-181c is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-181c-5p

Accession MIMAT0000258
Description Homo sapiens hsa-miR-181c-5p mature miRNA
Sequence 27 - AACAUUCAACCUGUCGGUGAGU - 48
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-181c-3p

Accession MIMAT0004559
Description Homo sapiens hsa-miR-181c-3p mature miRNA
Sequence 65 - AACCAUCGACCGUUGAGUGGAC - 86
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540