miRBase entry: hsa-mir-101-1

Stem-loop hsa-mir-101-1


Accession
MI0000103
Symbol
HGNC: MIR101-1
Description
Homo sapiens hsa-mir-101-1 precursor miRNA
Gene family
MIPF0000046; mir-101

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR101-1 is a microRNA-containing precursor that has been found to decrease significantly in LT and Ar compared to IBA in various brain regions [PMC7848201]. It is one of the miRNA precursors that showed the highest fold-changes in expression [PMC7848201]. MIR101-1 is also included in the top-ranked miRNA expression signatures [PMC9284388]. It has been identified as one of the differentially expressed genes (DEGs) related to Th2 cells and MAIT cells [PMC9380889]. The G-allele of rs11594111 extends the continuous complementary sequence to MIR101-1 from 7 nucleotides to 11 nucleotides [PMC3198095]. However, SUV39H2 mRNA is not predicted to be a target for MIR101-1 [PMC3198095]. In small RNA-seq datasets, MIR101-1 has uniquely aligned read pairs, while its paralogue MIR101-2 does not have any assigned read pairs [PMC6901076]. In Parkinson's disease patients, MIR101-1 has been found to be notably down-regulated along with other miRNAs such as miR-133b, miR218-2, and miR107 [PMC5288660].

References:
[PMC7848201] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848201/
[PMC9284388] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284388/
[PMC9380889] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380889/
[PM3198095] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM3198095/
[PM6901076] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM6901076/
[PMC5288660] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288660/

Literature search
307 open access papers mention hsa-mir-101-1
(2239 sentences)

Sequence

1180657 reads, 3806 reads per million, 145 experiments
ugcccuggcuCAGUUAUCACAGUGCUGAUGCUgucuauucuaaaggUACAGUACUGUGAUAACUGAAggauggca
((((.....((((((((((((((((((.((((............)))))))))))))))))))))).....))))

Structure
    cuggc                  A    gucua 
ugcc     uCAGUUAUCACAGUGCUG UGCU     u
||||     |||||||||||||||||| ||||      
acgg     AGUCAAUAGUGUCAUGAC AUgg     u
    uaggA                  -    aaauc 


Annotation confidence High
Do you think this miRNA is real?
Comments
Reference [1] reports two miR-101 precursor hairpin structures in human, on chromosome 1 (MIR:MI0000103) and 9 (MIR:MI0000739, named mir-101-precursor-9 in [1]). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr1: 65058434-65058508 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-101-1
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-101-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-101-5p

Accession MIMAT0004513
Description Homo sapiens hsa-miR-101-5p mature miRNA
Sequence 11 - CAGUUAUCACAGUGCUGAUGCU - 32
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-101-3p

Accession MIMAT0000099
Description Homo sapiens hsa-miR-101-3p mature miRNA
Sequence 47 - UACAGUACUGUGAUAACUGAA - 67
Evidence experimental
cloned [1-4]
Database links
Predicted targets

References

  1. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728