miRBase entry: hsa-mir-99a

Stem-loop hsa-mir-99a


Accession
MI0000101
Symbol
HGNC: MIR99A
Description
Homo sapiens hsa-mir-99a precursor miRNA
Gene family
MIPF0000033; mir-10

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR99A is a microRNA that can regulate NOX4 expression by targeting the 3’-UTR [PMC7407884]. In a study on plasma miRNAs in CAP (community-acquired pneumonia), MIR99A was found to be among the most elevated miRNAs [PMC8358855].

Literature search
196 open access papers mention hsa-mir-99a
(1198 sentences)

Sequence

393619 reads, 1967 reads per million, 159 experiments
cccauuggcauaAACCCGUAGAUCCGAUCUUGUGgugaaguggaccgcaCAAGCUCGCUUCUAUGGGUCUGugucagugug
..((((((((((.(((((((((..(((.((((((.((........)))))))).)))..))))))))).))))))))))..

Structure
cc          A         UC   U      g  aag 
  cauuggcaua ACCCGUAGA  CGA CUUGUG ug   u
  |||||||||| |||||||||  ||| |||||| ||    
  gugacuguGU UGGGUAUCU  GCU GAACac gc   g
gu          C         UC   C      -  cag 


Annotation confidence High
Do you think this miRNA is real?
Comments
This sequence is localised to chromosome 21 and was named mir-99-21 in reference [1].

Genome context
chr21: 16539089-16539169 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-99a
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-99a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-99a-5p

Accession MIMAT0000097
Description Homo sapiens hsa-miR-99a-5p mature miRNA
Sequence 13 - AACCCGUAGAUCCGAUCUUGUG - 34
Evidence experimental
cloned [1-3]
Database links
Predicted targets

Mature hsa-miR-99a-3p

Accession MIMAT0004511
Description Homo sapiens hsa-miR-99a-3p mature miRNA
Sequence 50 - CAAGCUCGCUUCUAUGGGUCUG - 71
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728