miRBase entry: hsa-mir-30a

Stem-loop hsa-mir-30a


Accession
MI0000088
Symbol
HGNC: MIR30A
Description
Homo sapiens hsa-mir-30a precursor miRNA
Gene family
MIPF0000005; mir-30

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR30A is a type of microRNA that plays a role in various cellular processes [PMC6888542]. Targeting MIR30A has been shown to decrease autophagy and increase sensitivity to Imatinib in primary LMC cells [PMC6888542]. The human MIR30A loop sequence (MIR30Ahsp) has been chosen for its high expression of siRNAs [PMC2737240]. Inhibition of exosomal MIR30A has been found to attenuate the protective effect of EGCG in hypoxic injury [PMC7054242]. The miR-30 family members, including MIR30A, are encoded on different chromosomes in clustered pairs [PMC4873751]. In a study, the expression of various genes was found to be affected by MIR30A, including both upregulated and downregulated genes [PMC7260613]. Specifically, miR7b and MIR30A were found to target the unique OCs-specific fusogen DC-STAMP [PMC7504439].

Literature search
486 open access papers mention hsa-mir-30a
(2535 sentences)

Sequence

4160938 reads, 5468 reads per million, 158 experiments
gcgacUGUAAACAUCCUCGACUGGAAGcugugaagccacagaugggCUUUCAGUCGGAUGUUUGCAGCugc
(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).)))

Structure
   a            UC           -----   a 
gcg cUGUAAACAUCC  GACUGGAAGcu     gug a
||| ||||||||||||  |||||||||||     |||  
cgu GACGUUUGUAGG  CUGACUUUCgg     cac g
   C            --           guaga   c 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature sequences miR-30 [1] and miR-97 [2] appear to originate from the same precursor. Subsequent data confirm that both arms of the precursor appear to give rise to mature miRNA sequences (Pfeffer S, pers. comm.). Landgraf et al. later showed that the 5' product is the predominant one [5]. Related miRNAs are processed from the 5' arms of other precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736; mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).

Genome context
chr6: 71403551-71403621 [-]

Disease association
hsa-mir-30a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-30a-5p

Accession MIMAT0000087
Description Homo sapiens hsa-miR-30a-5p mature miRNA
Sequence 6 - UGUAAACAUCCUCGACUGGAAG - 27
Evidence experimental
cloned [2,4-6]
Database links
Predicted targets

Mature hsa-miR-30a-3p

Accession MIMAT0000088
Description Homo sapiens hsa-miR-30a-3p mature miRNA
Sequence 47 - CUUUCAGUCGGAUGUUUGCAGC - 68
Evidence experimental
cloned [1,4-5], Northern [1]
Database links
Predicted targets

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  6. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728