Stem-loop cel-let-7

Accession

MI0000001

Description

Caenorhabditis elegans cel-let-7 precursor miRNA

Gene family

MIPF0000002; let-7

Literature search

81 open access papers mention cel-let-7
(1513 sentences)

Sequence

3797301 reads, 15959 reads per million, 16 experiments

uacacuguggauccggUGAGGUAGUAGGUUGUAUAGUUuggaauauuaccaccggugaaCUAUGCAAUUUUCUACCUUACCggagacagaacucuucga
.....(.((..(((((((((((((.((((((((((((........(((((...))))))))))))))))).)))))))))))))..)).).........

Structure

----uacac g  ga             U            Uuggaaua     a 
         u ug  uccggUGAGGUAG AGGUUGUAUAGU        uuacc  
         | ||  ||||||||||||| ||||||||||||        ||||| c
         a ac  aggCCAUUCCAUC UUUAACGUAUCa        agugg  
agcuucuca g  ag             U            --------     c 

Annotation confidence High

Comments

let-7 is found on chromosome X in Caenorhabditis elegans [1] and pairs to sites within the 3' untranslated region (UTR) of target mRNAs, specifying the translational repression of these mRNAs and triggering the transition to late-larval and adult stages [2].

Genome context

chrX: 14744173-14744271 [-]

Mature cel-let-7-5p

• Accession: MIMAT0000001
• Description: Caenorhabditis elegans cel-let-7-5p mature miRNA
• Sequence: 17 - UGAGGUAGUAGGUUGUAUAGUU - 38
• Evidence: experimental ; cloned [1-3], Northern [1], PCR [4], 454 [5], Illumina [6], CLIPseq [7]

Mature cel-let-7-3p

• Accession: MIMAT0015091
• Description: Caenorhabditis elegans cel-let-7-3p mature miRNA
• Sequence: 60 - CUAUGCAAUUUUCUACCUUACC - 81
• Evidence: experimental ; CLIPseq [7]

References

1. PubMed ID: 11679671
   An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
   "Lau NC, Lim LP, Weinstein EG, Bartel DP"
   "Science (2001) 294:858-862


2. PubMed ID: 12672692
   The microRNAs of Caenorhabditis elegans
   "Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP"
   "Genes Dev (2003) 17:991-1008


3. PubMed ID: 12747828
   MicroRNAs and other tiny endogenous RNAs in C. elegans
   "Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D"
   "Curr Biol (2003) 13:807-818


4. PubMed ID: 12769849
   Computational and experimental identification of C. elegans microRNAs
   "Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J"
   "Mol Cell (2003) 11:1253-1263


5. PubMed ID: 17174894
   Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
   "Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H, Bartel DP"
   "Cell (2006) 127:1193-1207


6. PubMed ID: 19460142
   Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
   Kato M, de Lencastre A, Pincus Z, Slack FJ
   Genome Biol (2009) 10:R54


7. PubMed ID: 20062054
   Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
   "Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW"
   "Nat Struct Mol Biol (2010) 17:173-179