miRBase entry: bta-mir-378b

Stem-loop bta-mir-378b

Bos taurus bta-mir-378b precursor miRNA
Gene family
MIPF0000168; mir-378

Caution, this is an AI generated summary based on literature. This may have errors. ?

Bta-mir-378b is a down-regulated microRNA in multiple intestinal regions of super-shedding (SS) cattle, suggesting its potential role in altering lipid metabolism and immune functions in the intestinal tract [PMC7959717]. It is a member of the miR-378 gene family, which has been implicated in regulating lipogenesis in adipose tissues [PMC7959717]. In the recto-anal junction (RAJ), bta-mir-378b is negatively correlated with PRDM1 and CYLD, genes associated with humoral and cell-mediated immune responses [PMC7959717]. In all intestinal regions, the target transcripts negatively correlated with bta-mir-378b are enriched for immune functions [PMC7959717'>PMC7959717'>PMC7959717'>PMC7959717'>PMC7959717]. It is worth investigating whether bta-mir-378b directly targets immune-related genes or regulates immune functions through lipid metabolism [PMC7959717]. The down-regulation of bta-mir-378b is associated with an increased expression of PRDM1 and CYLD in RAJ, which may be influenced by translocation of Gram-negative bacteria when the host intestinal mucosal barrier is disrupted or immune defenses are deficient [PMC7959717]. Bta-mir-378b down-regulation suggests its important role in E. coli O157 super-shedding [PMC7959717]. In the distal jejunum, several transcripts are negatively correlated with bta-miR-18a, bta-mir-378b, and bta-miR-2284d between non-super-shedding (NS) and SS cattle. These transcripts are associated with cell-mediated immune responses and hematological system development [PMC7959717]. Bta-mir-378b is down-regulated across all intestinal regions of SS cattle, indicating its potential significance in E. coli O157 super-shedding [PMC7959717].

Literature search
24 open access papers mention bta-mir-378b
(101 sentences)


914 reads, 286 reads per million, 67 experiments

c      accagggaaauccuga     -    uua     - --ggag    ag 
 uggacc                uuuug uuuc   uuaag g      guuc  u
 ||||||                ||||| ||||   ||||| |      ||||   
 accugg                AAGAC GAGG   AGUUC c      cgag  a
a      ----------auuCGG     U    UUC     A gacaaa    au 

Annotation confidence Not enough data
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Genome context
chr15: 30904740-30904837 [+]

Database links

Mature bta-miR-378b

Accession MIMAT0025535
Description Bos taurus bta-miR-378b mature miRNA
Evidence experimental
Illumina [1]


  1. PubMed ID: 21912509
    Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in Holstein cattle
    "Huang J, Ju Z, Li Q, Hou Q, Wang C, Li J, Li R, Wang L, Sun T, Hang S, Gao Y, Hou M, Zhong J"
    "Int J Biol Sci (2011) 7:1016-1026