Stem-loop bta-mir-2904-3

Accession

MI0013082

Description

Bos taurus bta-mir-2904-3 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Bta-mir-2904 is a microRNA (miRNA) identified among the top 10 differentially expressed miRNAs in a study, suggesting its potential biological significance [PMC9810022]. This miRNA is associated with a bacterial cluster that includes Prevotella and Bacteroides, indicating its possible role in the bovine microbiome [PMC6708143]. Bta-mir-2904 exhibits a high diversity of isomiRs, with over 100 variants identified at both the 5' and 3' ends, which may reflect its complex regulatory functions [PMC4609085]. It was also found to be highly expressed in the SA group of bulls compared to controls, suggesting its involvement in specific physiological or pathological processes [PMC6896338]. Additionally, bta-mir-2904 was prevalently expressed in low fertility (LF) bulls and identified as targeting the IL1A gene as well as DHX58, which is involved in pathogen recognition [PMC8329915], [PMC7943879]. Despite these associations with various regulatory functions, bta-mir-2904 expression was slightly downregulated when comparing low somatic cell count (SCC) to control groups [PMC8903571]. Moreover, its expression was lower during colostrum lactation compared to peak lactation [PMC5414302], and it was significantly enriched in heat stress-derived extracellular vesicles (HS-EVs) compared to control-EVs [PMC7519046].

Literature search

5 open access papers mention bta-mir-2904-3
(7 sentences)

Sequence

11057 reads, 1158 reads per million, 73 experiments

acggcagcgccgcGGGAGCCUCGGUUGGCCUCggauagccggucccccgccguccccgccggcgggccgu
(((((..(((((((((.((..(((..((((..((....))))))..)))..)).)))).))))).)))))

Structure

     ag     -    A  CU   UU    UC  a 
acggc  cgccg cGGG GC  CGG  GGCC  gg u
|||||  ||||| |||| ||  |||  ||||  ||  
ugccg  gcggc gccc ug  gcc  cugg  cc a
     -g     c    c  cc   cc    --  g 

Annotation confidence Low

Genome context

chr3: 53705747-53705816 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from bta-mir-2904-3

Mature bta-miR-2904

• Accession: MIMAT0013862
• Description: Bos taurus bta-miR-2904 mature miRNA
• Sequence: 14 - GGGAGCCUCGGUUGGCCUC - 32
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 19765282
   Identification and characterization of miRNAs expressed in the bovine ovary
   Hossain MM, Ghanem N, Hoelker M, Rings F, Phatsara C, Tholen E, Schellander K, Tesfaye D
   BMC Genomics (2009) 10:443