Stem-loop mmu-mir-878

Accession

MI0005548

Symbol

MGI: Mir878

Description

Mus musculus mmu-mir-878 precursor miRNA mir-878

Gene
family

RF03492; mir-878

Literature search

3 open access papers mention mmu-mir-878
(4 sentences)

Sequence

96065 reads, 1077 reads per million, 42 experiments

ugcaaugcuuUAUCUAGUUGGAUGUCAAGACAcgugaaacuuaaguGCAUGACACCACACUGGGUAGAggagggcuca
.((..(.((((((((((((((.(((((.(.(((...........)))).)))))))).))))))))))).)..))...

Structure

--u  aa g           -   A     A A   guga 
   gc  u cuuUAUCUAGU UGG UGUCA G CAc    a
   ||  | ||||||||||| ||| ||||| | |||    a
   cg  a gAGAUGGGUCA ACC ACAGU C Gug    c
acu  gg g           C   -     A -   aauu 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chrX: 66801508-66801585 [-]

Clustered miRNAs

6 other miRNAs are < 10 kb from mmu-mir-878

Mature mmu-miR-878-5p

• Accession: MIMAT0004932
• Description: Mus musculus mmu-miR-878-5p mature miRNA
• Sequence: 11 - UAUCUAGUUGGAUGUCAAGACA - 32
• Evidence: experimental ; cloned [2], 454 [3], Illumina [4-5]

Mature mmu-miR-878-3p

• Accession: MIMAT0004933
• Description: Mus musculus mmu-miR-878-3p mature miRNA
• Sequence: 47 - GCAUGACACCACACUGGGUAGA - 68
• Evidence: experimental ; cloned [2], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


5. PubMed ID: 17989215
   RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
   "Calabrese JM, Seila AC, Yeo GW, Sharp PA"
   "Proc Natl Acad Sci U S A (2007) 104:18097-18102