Stem-loop mmu-mir-376c

Accession

MI0003533

Symbol

MGI: Mir376c

Description

Mus musculus mmu-mir-376c precursor miRNA mir-368

Gene
family

RF04291; mir-368

Literature search

24 open access papers mention mmu-mir-376c
(42 sentences)

Sequence

13249 reads, 204 reads per million, 72 experiments

uuugguauuuaaaagGUGGAUAUUCCUUCUAUGUUUAugcuuuuugugauuaAACAUAGAGGAAAUUUCACGUuuucagugucaaa
.((((((((.((((.(((((..(((((.(((((((((..(.......)..))))))))))))))..))))).)))).)))))))).

Structure

u        u    g     UA     U         ug uu 
 uugguauu aaaa GUGGA  UUCCU CUAUGUUUA  c  u
 |||||||| |||| |||||  ||||| |||||||||  |  u
 aacuguga uuuU CACUU  AAGGA GAUACAAau  g  u
a        c    G     UA     -         ua ug 

Annotation confidence High

Comments

The mature miR-376c products have been shown to be modified by A to I edits [2].

Genome context

chr12: 109722718-109722803 [+]

Clustered miRNAs

17 other miRNAs are < 10 kb from mmu-mir-376c

Mature mmu-miR-376c-5p

• Accession: MIMAT0005295
• Description: Mus musculus mmu-miR-376c-5p mature miRNA
• Sequence: 16 - GUGGAUAUUCCUUCUAUGUUUA - 37
• Evidence: experimental ; cloned [1], Illumina [4-5]

Mature mmu-miR-376c-3p

• Accession: MIMAT0003183
• Description: Mus musculus mmu-miR-376c-3p mature miRNA
• Sequence: 53 - AACAUAGAGGAAAUUUCACGU - 73
• Evidence: experimental ; cloned [1], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


5. PubMed ID: 17322061
   Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
   "Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K"
   "Science (2007) 315:1137-1140