Stem-loop mmu-mir-7b

Accession

MI0000730

Symbol

MGI: Mir7b

Description

Mus musculus mmu-mir-7b precursor miRNA

Literature search

114 open access papers mention mmu-mir-7b
(1009 sentences)

Sequence

17340 reads, 141 reads per million, 55 experiments

aggagcggaguacgugagccagugcuaugUGGAAGACUUGUGAUUUUGUUGUUcugauaugauaugaCAACAAGUCACAGCCAGCCUCAuagcguggacuccuaucaccuu
..((..(((((.......(((.(((((((.((.....(((((((((.((((((.((......)).)))))))))))))))....)).)))))))))))))))..)).....

Structure

---ag  gc     acgugag   g       U  AAGAC         U      c  au 
     ga  ggagu       cca ugcuaug GG     UUGUGAUUU GUUGUU ug  a
     ||  |||||       ||| ||||||| ||     ||||||||| |||||| ||   
     cu  ccuca       ggu gcgauAC CC     GACACUGAA CAACag au  u
uucca  au     -------   -       U  -GACC         -      u  ag 

Annotation confidence High

Comments

miR-7 was predicted by computational methods using conservation between mouse, human and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. This sequence represents the mouse homologue of human mir-7-3 -- the derived mature form differs at a single position from that expressed from mir-7-1 (MIR:MI0000728) and mir-7-2 (MIR:MI0000729) in mouse, and mir-7-1 (MIR:MI0000263), mir-7-2 (MIR:MI0000264) and mir-7-3 (MIR:MI0000265) in human.

Genome context

chr17: 56242988-56243098 [+]

Mature mmu-miR-7b-5p

• Accession: MIMAT0000678
• Description: Mus musculus mmu-miR-7b-5p mature miRNA
• Sequence: 30 - UGGAAGACUUGUGAUUUUGUUGUU - 53
• Evidence: experimental ; cloned [2], Illumina [3-4]

Mature mmu-miR-7b-3p

• Accession: MIMAT0017071
• Description: Mus musculus mmu-miR-7b-3p mature miRNA
• Sequence: 68 - CAACAAGUCACAGCCAGCCUCA - 89
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009