miRBase entry: mmu-mir-222

Stem-loop mmu-mir-222


Accession
MI0000710
Symbol
MGI: Mir222
Description
Mus musculus mmu-mir-222 precursor miRNA mir-221
Gene
family?
RF00651; mir-221

Literature search
123 open access papers mention mmu-mir-222
(1029 sentences)

Sequence

439843 reads, 2137 reads per million, 108 experiments
cccucaguggCUCAGUAGCCAGUGUAGAUCCugucuuugguaaucagcAGCUACAUCUGGCUACUGGGUCUcugguggc
((.((((.(((((((((((((((((((...(((...........)))...))))).)))))))))))))).)))).)).

Structure
-  c    u              -     AUC   ucuu 
 cc ucag ggCUCAGUAGCCAG UGUAG   Cug    u
 || |||| |||||||||||||| |||||   |||    g
 gg gguc CUGGGUCAUCGGUC ACAUC   gac    g
c  u    U              U     GAc   uaau 


Annotation confidence High
Do you think this miRNA is real?
Comments
Mouse mir-222 is predicted [2] based on homology to a reported miR from human (MIR:MI0000299) [1]. Its expression was later verified in mouse by cloning [3].

Genome context
chrX: 19146893-19146971 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from mmu-mir-222
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-222-5p

Accession MIMAT0017061
Description Mus musculus mmu-miR-222-5p mature miRNA
Sequence 11 - CUCAGUAGCCAGUGUAGAUCC - 31
Evidence experimental
454 [5], Illumina [6]
Database links
Predicted targets

Mature mmu-miR-222-3p

Accession MIMAT0000670
Description Mus musculus mmu-miR-222-3p mature miRNA
Sequence 49 - AGCUACAUCUGGCUACUGGGUCU - 71
Evidence experimental
cloned [3], Illumina [4,6]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  5. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  6. PubMed ID: 20668074
    Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
    "Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H"
    "J Virol (2010) 84:10266-10275