Stem-loop mmu-mir-223

Accession

MI0000703

Symbol

MGI: Mir223

Description

Mus musculus mmu-mir-223 precursor miRNA mir-223

Gene
family

RF00664; mir-223

Literature search

185 open access papers mention mmu-mir-223
(2051 sentences)

Sequence

516726 reads, 1568 reads per million, 96 experiments

ucuggccaucugcagugucacgcucCGUGUAUUUGACAAGCUGAGUUGgacacucugugugguagagUGUCAGUUUGUCAAAUACCCCAaguguggcucaugccuaucag
.((((......((((.((((((((..(.((((((((((((((......(((((((((.....))))))))))))))))))))))).)..)))))))).).)))...))))

Structure

u    ccaucu   - u        cC U              GAGUUG         u 
 cugg      gca g gucacgcu  G GUAUUUGACAAGCU      gacacucug g
 ||||      ||| | ||||||||  | ||||||||||||||      ||||||||| u
 gacu      cgu c cgguguga  C CAUAAACUGUUUGA      CUGUgagau g
-    ---auc   a u        AC C              ------         g 

Annotation confidence High

Comments

Mouse mir-223 is predicted [2] based on homology to a reported miR from human (MIR:MI0000300) [1]. Its expression was later verified by cloning [3].

Genome context

chrX: 96242817-96242926 [+]

Mature mmu-miR-223-5p

• Accession: MIMAT0017056
• Description: Mus musculus mmu-miR-223-5p mature miRNA
• Sequence: 26 - CGUGUAUUUGACAAGCUGAGUUG - 48
• Evidence: experimental ; Illumina [5]

Mature mmu-miR-223-3p

• Accession: MIMAT0000665
• Description: Mus musculus mmu-miR-223-3p mature miRNA
• Sequence: 68 - UGUCAGUUUGUCAAAUACCCCA - 89
• Evidence: experimental ; cloned [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


5. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73