miRBase entry: mmu-mir-216a

Stem-loop mmu-mir-216a


Accession
MI0000699
Symbol
MGI: Mir216a
Description
Mus musculus mmu-mir-216a precursor miRNA mir-216
Gene
family?
RF00654; mir-216

Literature search
24 open access papers mention mmu-mir-216a
(164 sentences)

Sequence

1811 reads, 66 reads per million, 29 experiments
uugguuUAAUCUCAGCUGGCAACUGUGAgaugucccuaucauuccuCACAGUGGUCUCUGGGAUUAUGcuaa
.((((.(((((((((..(((.(((((((((((.......)))..)))))))).))).))))))))).)))).

Structure
u    u         CU   A        --   uc 
 uggu UAAUCUCAG  GGC ACUGUGAg  aug  c
 |||| |||||||||  ||| ||||||||  |||  c
 aucG AUUAGGGUC  CUG UGACACuc  uac  u
a    U         -U   G        cu   ua 


Annotation confidence High
Do you think this miRNA is real?
Comments
Mouse mir-216 is predicted [2] based on homology to a reported miR from human (MIR:MI0000292) [1]. Its expression was later verified by cloning [3].

Genome context
chr11: 28757012-28757083 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from mmu-mir-216a
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-216a-5p

Accession MIMAT0000662
Description Mus musculus mmu-miR-216a-5p mature miRNA
Sequence 7 - UAAUCUCAGCUGGCAACUGUGA - 28
Evidence experimental
cloned [3], Illumina [4]
Database links
Predicted targets

Mature mmu-miR-216a-3p

Accession MIMAT0017054
Description Mus musculus mmu-miR-216a-3p mature miRNA
Sequence 47 - CACAGUGGUCUCUGGGAUUAUG - 68
Evidence experimental
Illumina [4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  3. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  4. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73